Search Results - balasubramanyam+karanam

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Novel Bis-benzylidine Piperidone-based Proteasome Inhibitors with Anticancer Activity

Unmet NeedA hallmark of many human cancers is the proteasomal degradation of tumor suppressor proteins, leading to apoptosis arrest and sustained cell proliferation. Yet, to date, the therapeutic use of proteasome inhibitors is impeded by the grave side effects and emergence of disease resistance. This invention provides the novel small molecule proteasome...

Published: 3/13/2025 | Inventor(s): Balasubramanyam Karanam, Ravi Anchoori, Richard Roden

Keywords(s): Antagonists/Inhibitors, Cancers, Disease Indication, Small Molecules, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities > Small Molecules, Technology Classifications > Therapeutic Modalities