Search Results - brittany+dunkerly-eyring

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Targeting TSC2 S1366 (mouse, rat) S1365 (human) by gene engineering or phosphorylation to Regulate mTOR Signaling Cascades for Therapeutic Indications

Unmet NeedThe mechanistic target of rapamycin complex-1 (mTORC1) coordinates cellular processes and regulates recycling pathways in order to control cell growth and metabolic homeostasis. Additionally, in immune cells when the T-cell receptor is activated, the mTORC1 signaling pathway is also engaged and thus plays an important role in T-cell activation,...

Published: 10/4/2024 | Inventor(s): David Kass, Kristen Kokkonen, Brittany Dunkerly-Eyring, Mark Ranek

Keywords(s): Disease Indication, Inflammatory Disorders, Target, Therapeutic Matter, Therapeutics

Category(s): Technology Classifications > Therapeutic Modalities > Targets