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Targeting TSC2 S1366 (mouse, rat) S1365 (human) by gene engineering or phosphorylation to Regulate mTOR Signaling Cascades for Therapeutic Indications
Unmet NeedThe mechanistic target of rapamycin complex-1 (mTORC1) coordinates cellular processes and regulates recycling pathways in order to control cell growth and metabolic homeostasis. Additionally, in immune cells when the T-cell receptor is activated, the mTORC1 signaling pathway is also engaged and thus plays an important role in T-cell activation,...
Published: 3/14/2025
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Inventor(s):
David Kass
,
Kristen Kokkonen
,
Brittany Dunkerly-Eyring
,
Mark Ranek
Keywords(s):
Disease Indication
,
Inflammatory Disorders
,
Target
,
Therapeutic Matter
,
Therapeutics
Category(s):
Technology Classifications > Therapeutic Modalities > Targets
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