Search Results - mark+ranek

3 Results

Sort By:

Organ-On-A-Chip Mold with Microfluidics System

Value Proposition:3D printed mold that will allow for the rapid production of chips. Improved mold design allows microfluidics between multiple cell types.Multiple organoids enable physiologically relevant therapeutic testing.Technology DescriptionResearchers at Johns Hopkins have developed a organ on a chip model to test organ interactions, pathological...

Published: 10/4/2024 | Inventor(s): Mark Ranek, Marcus Williams, Vivek Jani, Brian Lin

Keywords(s):

Category(s): Technology Classifications > Research Tools > Microfluidics, Technology Classifications > Medical Devices > Therapeutic Devices, Technology Classifications > Computers, Electronics & Software > Precision Medicine Tools

New Method of mTOR Regulation by TSC2 Modification

Unmet NeedImmunotherapies that boost T cell responses have demonstrated therapeutic efficacy in numerous cancers. To improve the efficacy and expand the clinical utility of immunotherapy, improved methods of stimulating T cell responses are needed. mTORC1 is a critical regulator of T cell activation, differentiation and function. While modulating mTORC1...

Published: 10/4/2024 | Inventor(s): David Kass, Mark Ranek, Kristen Kokkonen, Jonathan Powell, Chirag Patel

Keywords(s): Cancers, Cell Therapy/Gene Therapy, Combination, Disease Indication, Therapeutic Matter, Therapeutics, Therapy Type

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities > Cell Therapies, Technology Classifications > Therapeutic Modalities > Gene Therapies, Technology Classifications > Therapeutic Modalities

Targeting TSC2 S1366 (mouse, rat) S1365 (human) by gene engineering or phosphorylation to Regulate mTOR Signaling Cascades for Therapeutic Indications

Unmet NeedThe mechanistic target of rapamycin complex-1 (mTORC1) coordinates cellular processes and regulates recycling pathways in order to control cell growth and metabolic homeostasis. Additionally, in immune cells when the T-cell receptor is activated, the mTORC1 signaling pathway is also engaged and thus plays an important role in T-cell activation,...

Published: 10/4/2024 | Inventor(s): David Kass, Kristen Kokkonen, Brittany Dunkerly-Eyring, Mark Ranek

Keywords(s): Disease Indication, Inflammatory Disorders, Target, Therapeutic Matter, Therapeutics

Category(s): Technology Classifications > Therapeutic Modalities > Targets