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New Method of mTOR Regulation by TSC2 Modification

Unmet NeedImmunotherapies that boost T cell responses have demonstrated therapeutic efficacy in numerous cancers. To improve the efficacy and expand the clinical utility of immunotherapy, improved methods of stimulating T cell responses are needed. mTORC1 is a critical regulator of T cell activation, differentiation and function. While modulating mTORC1...

Published: 10/4/2024 | Inventor(s): David Kass, Mark Ranek, Kristen Kokkonen, Jonathan Powell, Chirag Patel

Keywords(s): Cancers, Cell Therapy/Gene Therapy, Combination, Disease Indication, Therapeutic Matter, Therapeutics, Therapy Type

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities > Cell Therapies, Technology Classifications > Therapeutic Modalities > Gene Therapies, Technology Classifications > Therapeutic Modalities