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Reprograming the Cancer Cells with Epigenetic Therapy (DNA Demethylating Agents and Histone Deacetylase Inhibitors) Sensitizes Multiple Cancers to PARP Inhibitors

Combinatorial Drug Therapy for CancersJHU REF: [C12345]Invention novelty: a combinatorial drug therapy for leukemia, ovarian, breast and lung cancers by targeting both epigenetic and DNA repair pathways.Value PropositionConventional forms of cancer drug therapy are limited in their results once the cancers exhibit resistance to existing drug regimens....

Published: 6/27/2024 | Inventor(s): Nidal Muvarak, Feyruz Rassool, Carine Robert, Stephen Baylin

Keywords(s): Antagonists/Inhibitors, Cancers, Combination, Disease Indication, Non-novel, Predicted Novelty, Repurposed, Small Molecules, Targeted Therapy/Targeted Therapy, Therapeutic Matter, Therapeutic Substance, Therapeutics, Therapy Type

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities > Small Molecules, Technology Classifications > Therapeutic Modalities > Targets, Technology Classifications > Therapeutic Modalities