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Rare HOXB13 African Ancestry-specific Gene Mutation: A Promising Prostate Cancer (PCa) Susceptibility Biomarker

Value PropositionIncorporation of the X285K variant of the HOXB13 gene for screening diagnosis or targeted drug discovery will identify and target early-onset and more aggressive prostate cancer disease in higher risk populations. No other HOXB13 variant has been found to be preferentially associated with risk for aggressive prostate cancer, making...

Published: 6/27/2025 | Inventor(s): William Isaacs, Jun Luo, Mayuko Kanayama

Keywords(s):

Category(s): Clinical and Disease Specializations > Research Tools > Assays, Clinical and Disease Specializations > Urology

A Novel Supramolecular High Affinity Protein-Binding System for Purification of Biomacromolecules

Market hold: no patent application filed for this invention.Unmet Need· It is estimated that between ~50-80% of costs in antibody production are spent in purification (Mustafaoglu et al. 2016), which is typically performed by affinity chromatography. Although this method has adequate binding affinity and selectivity, the process remains costly...

Published: 6/26/2025 | Inventor(s): Honggang Cui, Yi Li, Lye Lin Lock, XuanKuo Xu, Zhengjian Li

Keywords(s): Therapeutic Matter, Therapeutic Substance Synthesis Method, Therapeutics

Category(s): Technology Classifications > Therapeutic Modalities, Clinical and Disease Specializations > Research Tools > Assays, Technology Classifications > Research Tools > Antibodies, Technology Classifications > Diagnostics > Biomarkers