Search Results - emmanuel+akinboye

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Mechanism-based 3rd Generation Quinoline-3-carboxamide HDAC4 Inhibitor for Metastatic Castration-resistant Prostate Cancer

Value Proposition:· Metastatic castration-resistant prostate cancer (mCRPC) treatment that offers reduced side effects due to its mechanism of action (MoA)· HDAC4 inhibition prevents the upregulation of stress survival pathways, which in turn may prevent metastases in mCRPC· Similar anti-cancer agents must be dosed at lower concentrations...

Published: 10/4/2024 | Inventor(s): John Isaacs, William Brennen, Emmanuel Akinboye

Keywords(s):

Category(s): Clinical and Disease Specializations > Oncology > Prostate Cancer, Clinical and Disease Specializations > Oncology

Novel prodrug strategy to improve clinical use of cancer drugs

Unmet Need / Invention Novelty: Clinical translation of various has been limited due to poor solubility and toxicity for repurposed anti-cancer applications. There exists an unmet need to develop new strategies to overcome these limitations. Technical Details: Researchers at Johns Hopkins have developed a novel prodrug strategy to improve solubility...

Published: 10/4/2024 | Inventor(s): William Brennen, John Isaacs, Samuel Denmeade, Emmanuel Akinboye

Keywords(s):

Category(s): Clinical and Disease Specializations > Oncology

A New Method to Suppress Background Noise in Stimulated Emission Depletion (STED) Nanoscopy

Unmet NeedDifferentiating small features, such a membrane fibrils in a cell, or small entities, such as viruses, is made possible by high resolution fluorescence imaging. Stimulated Emission Depletion (STED) Nanoscopy has proven to produce images that can overcome the diffraction limit and provide nanometer resolution of fluorescently labeled samples....

Published: 10/4/2024 | Inventor(s): Taekjip Ha, Jong-Chan Lee, Ye Ma

Keywords(s):

Category(s): Technology Classifications > Diagnostics > Diagnostic Imaging