Search Results - jeffery+coller

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mRNA Intensifier to treat Haploinsufficiencies

Unmet Need / Invention Novelty: Haploinsufficiency occurs when one gene allele is inactivated and the amount of gene product expressed from the remaining active allele is insufficient for proper gene function. Targeted restoration of mRNA expression and translation may offer a therapeutic window. Technical Details: Johns Hopkins researchers designed...

Published: 3/14/2025 | Inventor(s): Jeffery Coller, Bahareh Torkzaban

Keywords(s):

Category(s): Technology Classifications > Therapeutic Modalities > Gene Therapies, Technology Classifications > Therapeutic Modalities > Proteins

Compositions and Methods of Increasing RNA Translation

Value Proposition mRNA use for therapeutic purposes has proven useful in treating a wide array of diseases. Major challenges of mRNA therapies include immunogenicity, poor expression, and low stability. This therapy contains modifications improving mRNA stability, efficiency, and immunogenicity. This technology allows for the translation of almost...

Published: 3/14/2025 | Inventor(s): Jeffery Coller, Zachary Mandell

Keywords(s):

Category(s): Clinical and Disease Specializations, Technology Classifications > Therapeutic Modalities > Cell Therapies, Technology Classifications > Therapeutic Modalities > Gene Therapies, Technology Classifications > Therapeutic Modalities > Vaccines