Search Results - jeffrey+ruffolo

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Multiple-instance Learning on Antibody Repertoires for Detecting Specific Antibodies and Paratopes

Unmet NeedAntibodies are one of the most important tools in medicine. Although they have long been essential components of research experiments and diagnostic assays, their use as therapeutics is revolutionizing the treatment of many autoimmune and cancerous conditions. The antibody drug market is estimated at $126.7 billion (BCC Research) and the antibody...

Published: 6/28/2024 | Inventor(s): Jeremias Sulam, Jeffrey Ruffolo, Jeffrey Gray

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Category(s): Technology Classifications > Diagnostics > Diagnostic Biomarkers

Antibody Structure Prediction from Pre-trained Language Model (IgFold)

Inventor(s): Jeffrey Ruffolo and Jeffrey Gray Unmet Need: Antibodies are able to bind a diverse set of antigens and have become critical therapeutics and diagnostic molecules. Antibody binding is facilitated by a set of six hypervariable loops that are diversified through genetic recombination and mutation. An accurate structural model of the hypervariable...

Published: 6/28/2024 | Inventor(s): Jeffrey Gray, Jeffrey Ruffolo

Keywords(s):

Category(s): Copyright, Technology Classifications > Computers, Electronics & Software > Algorithms, Technology Classifications > Computers, Electronics & Software > Artificial Intelligence, Technology Classifications > Computers, Electronics & Software > Machine Learning, Technology Classifications > Research Tools > Antibodies