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Compositions and methods for controlled release suprachoroidal drug delivery

Unmet Need / Invention Novelty: Traditional routes of administrating drugs to the eye are limited by lack of efficiency, frequent side effects, and poor patient tolerance of repeated injections into the eye. Injections into the suprachoroidal space (SCS) is an attractive strategy to overcome these limitations and to provide for targeted delivery of...

Published: 6/28/2024 | Inventor(s): Laura Ensign-Hodges, Peter Campochiaro, Justin Hanes, Yoo Chun Kim, Jikui Shen, Jie Fu

Keywords(s): Disease Indication, Drug Delivery Mechanism, Drug Delivery Vehicle, Eye Disorders, Hydrogel, Local Ocular, Microspheres, Polymers, Therapeutic Matter, Therapeutics

Category(s): Clinical and Disease Specializations > Ophthalmology, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms

Glutaminase Inhibitor Discovery and Nanoparticle-Enhanced Delivery for Cancer Therapy

Glutaminase Inhibitor Discovery and Nanoparticle-Enhanced Delivery for cancer therapyJHU REF: C13142 Invention novelty: An improved glutaminase (GLS) inhibitors delivery system to enhance efficacy and prolong glutaminase inhibitor drug levels in tumor for improve treatment of pancreatic cancer. Value Proposition: Currently available glutaminase inhibitors...

Published: 6/27/2024 | Inventor(s): Barbara Slusher, Jie Fu, Justin Hanes, Qingguo Xu, Quy Hoa Le Thi, Takashi Tsukamoto

Keywords(s): Adenocarcinoma, Antagonists/Inhibitors, Cancers, Disease Indication, Drug Delivery Vehicle, Nanoparticles, Non-novel, Off-the-shelf, Pancreatic Cancer, Pancreatic ductal adenocarcinoma, Pancreatic Ductal Adenocarcinoma, Predicted Novelty, Small Molecules, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Gastroenterology, Clinical and Disease Specializations > Oncology > Adenocarcinoma, Clinical and Disease Specializations > Oncology > Pancreatic Cancer, Clinical and Disease Specializations > Oncology > Pancreatic Ductal Adenocarcinoma, Technology Classifications > Therapeutic Modalities > Small Molecules, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities