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Combined MAPK and NAMPT Inhibition: Greater Efficacy in Axonal Degeneration

Value PropositionDemonstrates synergistic effect of targeting two biochemical pathways.Offers possible disease-modifying therapy for degenerative diseases of the axons.Possible treatment to minimize damage from acute brain injury.Unmet NeedDegeneration of axons is a hallmark feature of various neurological conditions. Deterioration of axons is observed...

Published: 6/28/2024 | Inventor(s): Vassilis Koliatsos, Athanasios Alexandris, Jiwon Ryu

Keywords(s):

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Neurology > Neuropathy, Clinical and Disease Specializations > Neurology > Neurodegeneration

SARM1 Inhibition or Deletion as Experimental Treatment of Traumatic Brain Injury and Neurodegenerative Disease

Unmet NeedTraumatic brain injury (TBI) is regarded as one of the major causes of death and disability in the United States, contributing to 30% of all injury-related deaths. Over 150 people die daily from consequences of a TBI and those that survive often face difficulties and disabilities that can last for the duration of their lives. TBIs range in...

Published: 6/27/2024 | Inventor(s): Vassilis Koliatsos, Nikolaos Ziogas, Athanasios Alexandris, Jiwon Ryu

Keywords(s): CNS and Neurological Disorders, Disease Indication, Neurodegenerative Diseases, Target, Therapeutic Matter, Therapeutics, Traumatic Injury

Category(s): Clinical and Disease Specializations > Neurology > Neurodegeneration, Technology Classifications > Therapeutic Modalities > Targets, Clinical and Disease Specializations > Traumatic Injury