Search Results - laura+ensign-hodges

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Local Sustained-release Nanocrystal Formulations to Treat and Prevent GI Fibrosis

Unmet Need: Gastrointestinal (GI) fibrosis, the accumulation of scar tissue in the intestinal wall as a complication in common GI autoimmune diseases such as ulcerative colitis (UC) and Crohn’s disease (CD), leads to intestinal strictures, abdominal pain, and reduced intestinal motility. Current pharmacological and surgical treatment methods have significant...

Published: 6/28/2024 | Inventor(s): Laura Ensign-Hodges, Florin Selaru, Min Kyung Joo, Rachel Shapiro, Ling Li

Keywords(s):

Category(s): Clinical and Disease Specializations > Gastroenterology

New use of Sulconazole to Treat and Prevent GI Fibrosis

Published: 6/28/2024 | Inventor(s): Florin Selaru, Laura Ensign-Hodges, Ling Li, Min Kyung Joo

Keywords(s):

Category(s): Clinical and Disease Specializations > Gastroenterology

Methods and Compositions for Achieving Sustained Intraocular Drug Delivery via Melanin Binding

Unmet Need / Invention Novelty: Intravitreal injection is the gold standard for achieving drug delivery to the posterior segment of the eye. However, achieving effective delivery is challenging and the injections need to be performed frequently which hinders patient compliance. There therefore exists an unmet need to develop a formulation for intraocular...

Published: 6/28/2024 | Inventor(s): Laura Ensign-Hodges, Justin Hanes, Yoo Chun Kim, Tung Heng Hsueh

Keywords(s):

Category(s): Technology Classifications > Therapeutic Modalities, Clinical and Disease Specializations > Ophthalmology

Compositions and methods for controlled release suprachoroidal drug delivery

Unmet Need / Invention Novelty: Traditional routes of administrating drugs to the eye are limited by lack of efficiency, frequent side effects, and poor patient tolerance of repeated injections into the eye. Injections into the suprachoroidal space (SCS) is an attractive strategy to overcome these limitations and to provide for targeted delivery of...

Published: 6/28/2024 | Inventor(s): Laura Ensign-Hodges, Peter Campochiaro, Justin Hanes, Yoo Chun Kim, Jikui Shen, Jie Fu

Keywords(s): Disease Indication, Drug Delivery Mechanism, Drug Delivery Vehicle, Eye Disorders, Hydrogel, Local Ocular, Microspheres, Polymers, Therapeutic Matter, Therapeutics

Category(s): Clinical and Disease Specializations > Ophthalmology, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms

Method for Cervicovaginal Secretion Transplants to Restore Healthy Vaginal Microbiota

Approximately one-third of all women currently have bacterial vaginosis (BV), a condition where the vaginal microbiota is not dominated by lactobacilli. Another one-third of women have mixed vaginal microbiota (intermediate BV), and only one-third of women have healthy, lactobacilli-dominated microbiota. Women with BV are known to have >2-6-fold...

Published: 6/27/2024 | Inventor(s): Justin Hanes, Richard Cone, Laura Ensign-Hodges

Keywords(s): Biologics, Disease Indication, Therapeutic Matter, Therapeutic Substance, Therapeutics, Transplant, Transplants, Women's Health

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Transplantation, Technology Classifications > Therapeutic Modalities > Biologics, Clinical and Disease Specializations > Microbiome, Clinical and Disease Specializations > Women's Health, Technology Classifications > Therapeutic Modalities

Methods to achieve enhanced delivery to the bladder

Unmet Need: Bladder cancer is a global disease, with 540,000 incident cases and 188,000 deaths in 2015 worldwide. In the United States 81,190 patients will be diagnosed in 2018 and 17,240 will die from their disease.(1) The first-line treatment of non-muscle-invasive bladder cancer (NMIBC) is the transurethral resection of bladder tumors (TURBT),...

Published: 6/27/2024 | Inventor(s): Laura Ensign-Hodges, Justin Hanes, Abhijit Date, Trinity Bivalacqua, Max Kates

Keywords(s): Bladder Cancer, Cancers, Chemotherapy, Disease Indication, Drug Delivery Vehicle, Nanoparticles, Single, Therapeutic Matter, Therapeutics, Therapy Type

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Urology, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Technology Classifications > Therapeutic Modalities > Small Molecules, Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities, Clinical and Disease Specializations > Oncology > Bladder Cancer

Ultra-thin, High Strength, Absorbable Sutures Capable of Controlled Drug Release

UNMET NEED There are a number of parameters that affect the electrospinning process including polymer, solvent, polymer: solvent ratio, flow rate, voltage, distance to collector, collector type and speed, and needle size.5 Typical electrospinning setups allow for the manufacture of aligned or random fiber mats composed of nano- or micro-fibers. These...

Published: 6/27/2024 | Inventor(s): Laura Ensign-Hodges, Justin Hanes, Kunal Parikh

Keywords(s): Drug Delivery Vehicle, Industrial Manufacturing, Polymers, Therapeutic Matter, Therapeutics

Category(s): Technology Classifications > Therapeutic Modalities, Technology Classifications > Therapeutic Modalities > Dendrimers & Polymers, Technology Classifications > Industrial Tech > Industrial Manufacturing, Technology Classifications > Engineering Tech > Industrial Manufacturing