Search Results - necrotizing+enterocolitis+(nec)

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Discovery of Novel Compounds that Enhance Enteric Nervous System Function

Unmet needNecrotizing enterocolitis (NEC), a condition of newborns in which a portion of the bowel dies. NEC affects one in 1000-4000 births, or about 10% of preterm children and is associated with an overall mortality of up to 40%. NEC is thought to be caused by defective bacterial-host signaling during colonization of the intestine with bacteria,...

Published: 3/14/2025 | Inventor(s): David Hackam, Peng Lu, Chhinder Sodhi

Keywords(s): Agonists/Promoters, Disease Indication, Inflammatory Disorders, Necrotizing Enterocolitis (NEC), Non-novel, Predicted Novelty, Repurposed, Small Molecules, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Technology Classifications > Therapeutic Modalities > Small Molecules, Technology Classifications > Therapeutic Modalities > Repurposed Drugs, Clinical and Disease Specializations > Inflammation > Necrotizing Enterocolitis

C34 triols in the treatment or prevention of inflammatory disorders in children and adults with a focus on necrotizing enterocolitis

Unmet Need Necrotizing enterocolitis (NEC) is the leading cause of death and disability in premature infants. The disease is characterized by a bacterial infection in the intestines that quickly progresses to organ death if untreated. Current treatment of NEC entails surgically removing the diseased parts of the intestine. However, this procedure leads...

Published: 3/13/2025 | Inventor(s): David Hackam, Chhinder Sodhi, Peter Wipf

Keywords(s): Antagonists/Inhibitors, Disease Indication, Inflammatory Disorders, Necrotizing Enterocolitis (NEC), Small Molecules, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Clinical and Disease Specializations > Inflammation > Necrotizing Enterocolitis, Technology Classifications > Therapeutic Modalities, Technology Classifications > Therapeutic Modalities > Small Molecules