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Gut-specific serotonin transporter inhibitors for treatment of constipation
Value Proposition· Potent inhibition of serotonin transporter (SERT) in GI system· Luminally and or/peripherally-restricted SERT inhibitors· Result in enhanced action of serotonin in stimulation of GI motility· Spares the body of systemic and CNS effectsUnmet NeedConstipation-predominant IBS involves reduced gastrointestinal...
Published: 3/13/2025
|
Inventor(s):
Pankaj Pasricha
,
James Barrow
,
Qian Li
,
Pablo de Leon
,
Yifang Huang
Keywords(s):
Antagonists/Inhibitors
,
Biomarker
,
Disease Indication
,
Gastrointestinal Disorders
,
Mechanism-of-action Biomarker
,
Non-novel
,
Predicted Novelty
,
Repurposed
,
Small Molecules
,
Therapeutic Matter
,
Therapeutic Substance
,
Therapeutics
Category(s):
Technology Classifications > Therapeutic Modalities > Targets
,
Clinical and Disease Specializations > Gastroenterology
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