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Gut-specific serotonin transporter inhibitors for treatment of constipation

Value Proposition· Potent inhibition of serotonin transporter (SERT) in GI system· Luminally and or/peripherally-restricted SERT inhibitors· Result in enhanced action of serotonin in stimulation of GI motility· Spares the body of systemic and CNS effectsUnmet NeedConstipation-predominant IBS involves reduced gastrointestinal...

Published: 3/13/2025 | Inventor(s): Pankaj Pasricha, James Barrow, Qian Li, Pablo de Leon, Yifang Huang

Keywords(s): Antagonists/Inhibitors, Biomarker, Disease Indication, Gastrointestinal Disorders, Mechanism-of-action Biomarker, Non-novel, Predicted Novelty, Repurposed, Small Molecules, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Technology Classifications > Therapeutic Modalities > Targets, Clinical and Disease Specializations > Gastroenterology

Treatment of Irritable Bowel Syndrome with Molybdenum

Unmet NeedIrritable Bowel Syndrome is a chronic and incurable gastrointestinal disorder that affects 3-20% of Americans depending on certain sociocultural and comorbid factors. A poorly understood condition, current treatments consist of antispasmodics, antidiarrheals, and dietary restrictions. Unable to alleviate all its symptoms, researchers are in...

Published: 3/13/2025 | Inventor(s): Pankaj Pasricha, Lian Sheng Liu, Qian Li, Alfred Spormann

Keywords(s): Disease Indication, Gastrointestinal Disorders, Inflammatory Bowel Disease (IBD), Small Molecules, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Technology Classifications > Therapeutic Modalities > Small Molecules, Clinical and Disease Specializations > Gastroenterology > Irritable Bowel Disease

Method of Treatment of Irritable Bowel Syndrome (KSL-W)

Value Proposition:· A synthetic antimicrobial peptide (AMP) that may be a potent therapeutic for irritable bowel syndrome (IBS) pain.· This AMP limits the growth of harmful bacteria, while not interfering with beneficial ones.· This AMP can be delivered directly to the colon, bypassing any degradation by the upper gastrointestinal...

Published: 3/14/2025 | Inventor(s): Pankaj Pasricha, Qian Li, Lian Sheng Liu, Phillip Phan

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