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INVENTION NOVELTYJohns Hopkins researchers have developed multiple unique inhibitors to DNA polymerase beta, a potential anti-cancer therapeutic target. VALUE PROPOSITIONThe DNA damaging agent temozolomide (TMZ) is used to treat melanoma and glioblastoma. TMZ damages cancer cell DNA by introducing single stranded breaks (SSBs). However TMZ’s efficacy...

Published: 3/13/2025 | Inventor(s): Marc Greenberg, Rakesh Paul

Keywords(s): Antagonists/Inhibitors, Cancers, Chemotherapy/Targeted Therapy, Combination, Disease Indication, Novel, Predicted Novelty, Small Molecules, Therapeutic Matter, Therapeutic Substance, Therapeutics, Therapy Type

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities > Small Molecules, Technology Classifications > Therapeutic Modalities