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Novel eIF2α kinase target and small molecule inhibitors for modulating translation and the stress response

Unmet Need / Invention Novelty: Few kinases have been identified that phosphorylate eukaryotic initiation factor 2 alpha (eIF2α) and control translation in response to protein unfolding stress, a common cause of various neurodegenerative diseases. There is an unmet need to identify novel eIF2α kinase targets modulating translation and stress-responses...

Published: 3/14/2025 | Inventor(s): Jiou Wang, YuNing Lu

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Category(s): Technology Classifications > Therapeutic Modalities > Small Molecules