Search Results - jiou+wang

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Novel eIF2α kinase target and small molecule inhibitors for modulating translation and the stress response

Unmet Need / Invention Novelty: Few kinases have been identified that phosphorylate eukaryotic initiation factor 2 alpha (eIF2α) and control translation in response to protein unfolding stress, a common cause of various neurodegenerative diseases. There is an unmet need to identify novel eIF2α kinase targets modulating translation and stress-responses...

Published: 3/14/2025 | Inventor(s): Jiou Wang, YuNing Lu

Keywords(s):

Category(s): Technology Classifications > Therapeutic Modalities > Small Molecules

Novel CRISPR-Cas based therapeutic strategy to decrease toxic RNA and protein products generated from nucleotide repeats

Unmet Need / Invention Novelty: Expansions in nucleotide repeat elements have been linked to various neurological and neuromuscular disorders, with repeat-containing RNAs and/or their protein products being identified as important causes of pathogenic processes and associated diseases. There is an unmet clinical need to develop of a novel therapeutic...

Published: 3/14/2025 | Inventor(s): Jiou Wang, Honghe Liu

Keywords(s):

Category(s): Technology Classifications > Therapeutic Modalities, Technology Classifications > Therapeutic Modalities > Gene Therapies

Transgenic Mice that Express Human Superoxide Dismutase 1 with the Following Mutations (1) a Double Mutation at Residue 46 and 48 with Histidine 46 Mutated to Arginine and Histidine 48 Mutated to Glutamine; (2) a Quadruple Mutation Where Histidine 46

C04495: Transgenic Mice that Express Human Superoxide Dismutase 1 with the Following Mutations (1) a Double Mutation at Residue 46 and 48 with Histidine 46 Mutated to Arginine and Histidine 48 Mutated to Glutamine; (2) a Quadruple Mutation Where Histidine 46 Technical Details: Mutations in superoxide dismutase 1 cause familial forms of amyotrophic...

Published: 3/13/2025 | Inventor(s): Hilda Slunt, Jiou Wang, David Borchelt

Keywords(s): Discovery/Research Tools, In Vivo Research Tool, Mouse Model, Mouse Model Xenograft, Translational Research Biomarker

Category(s): Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools