Search Results - david+borchelt

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N171-82Q Huntington's Disease (HD) Mouse Model

C05027: N171-82Q Huntington's Disease (HD) Mouse Model Technical Details: This transgenic line expresses an N-terminally truncated human huntingtin cDNA that encodes 82 glutamines and encompasses the first 171 amino acids. The altered huntingtin cDNA is under the control of a mouse prion protein promoter. Expression is observed in neurons of...

Published: 3/13/2025 | Inventor(s): Gabriele Schilling, David Borchelt, Christopher Ross

Keywords(s): Cell Lines, CNS and Neurological Disorders, Discovery/Research Tools, Disease Indication, Huntington's Disease, In Vitro Research Tool, In Vivo Research Tool, Mouse Cell Lines, Mouse Model, Neurodegeneration, Translational Research Biomarker

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Neurology > Huntington's Disease, Clinical and Disease Specializations > Neurology > Neurodegeneration, Clinical and Disease Specializations > Rare Diseases, Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools > Cell Lines, Clinical and Disease Specializations > Neurology, Technology Classifications > Research Tools

Transgenic Mice that Express Human Superoxide Dismutase 1 with the Following Mutations (1) a Double Mutation at Residue 46 and 48 with Histidine 46 Mutated to Arginine and Histidine 48 Mutated to Glutamine; (2) a Quadruple Mutation Where Histidine 46

C04495: Transgenic Mice that Express Human Superoxide Dismutase 1 with the Following Mutations (1) a Double Mutation at Residue 46 and 48 with Histidine 46 Mutated to Arginine and Histidine 48 Mutated to Glutamine; (2) a Quadruple Mutation Where Histidine 46 Technical Details: Mutations in superoxide dismutase 1 cause familial forms of amyotrophic...

Published: 3/13/2025 | Inventor(s): Hilda Slunt, Jiou Wang, David Borchelt

Keywords(s): Discovery/Research Tools, In Vivo Research Tool, Mouse Model, Mouse Model Xenograft, Translational Research Biomarker

Category(s): Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools