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N171-82Q Huntington's Disease (HD) Mouse Model
C05027: N171-82Q Huntington's Disease (HD) Mouse Model Technical Details: This transgenic line expresses an N-terminally truncated human huntingtin cDNA that encodes 82 glutamines and encompasses the first 171 amino acids. The altered huntingtin cDNA is under the control of a mouse prion protein promoter. Expression is observed in neurons of...
Published: 3/13/2025
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Inventor(s):
Gabriele Schilling
,
David Borchelt
,
Christopher Ross
Keywords(s):
Cell Lines
,
CNS and Neurological Disorders
,
Discovery/Research Tools
,
Disease Indication
,
Huntington's Disease
,
In Vitro Research Tool
,
In Vivo Research Tool
,
Mouse Cell Lines
,
Mouse Model
,
Neurodegeneration
,
Translational Research Biomarker
Category(s):
Clinical and Disease Specializations
,
Clinical and Disease Specializations > Neurology > Huntington's Disease
,
Clinical and Disease Specializations > Neurology > Neurodegeneration
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Clinical and Disease Specializations > Rare Diseases
,
Technology Classifications > Research Tools > Animal Models
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Technology Classifications > Research Tools > Cell Lines
,
Clinical and Disease Specializations > Neurology
,
Technology Classifications > Research Tools
Transgenic Mice that Express Human Superoxide Dismutase 1 with the Following Mutations (1) a Double Mutation at Residue 46 and 48 with Histidine 46 Mutated to Arginine and Histidine 48 Mutated to Glutamine; (2) a Quadruple Mutation Where Histidine 46
C04495: Transgenic Mice that Express Human Superoxide Dismutase 1 with the Following Mutations (1) a Double Mutation at Residue 46 and 48 with Histidine 46 Mutated to Arginine and Histidine 48 Mutated to Glutamine; (2) a Quadruple Mutation Where Histidine 46 Technical Details: Mutations in superoxide dismutase 1 cause familial forms of amyotrophic...
Published: 3/13/2025
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Inventor(s):
Hilda Slunt
,
Jiou Wang
,
David Borchelt
Keywords(s):
Discovery/Research Tools
,
In Vivo Research Tool
,
Mouse Model
,
Mouse Model Xenograft
,
Translational Research Biomarker
Category(s):
Technology Classifications > Research Tools > Animal Models
,
Technology Classifications > Research Tools
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