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Transgenic Mice that Express Human Superoxide Dismutase 1 with the Following Mutations (1) a Double Mutation at Residue 46 and 48 with Histidine 46 Mutated to Arginine and Histidine 48 Mutated to Glutamine; (2) a Quadruple Mutation Where Histidine 46

Technical Details: Mutations in superoxide dismutase 1 cause familial forms of amyotrophic lateral sclerosis (ALS). To investigate potential mechanisms of disease pathogenesis, transgenic mice that express human superoxide dismutase 1 with the following mutations were generated: (1) a double mutation at residue 46 and 48 with histidine 46 mutated...

Published: 6/12/2026 | Inventor(s): Hilda Slunt, Jiou Wang, David Borchelt

Keywords(s): Discovery/Research Tools, In Vivo Research Tool, Mouse Model, Mouse Model Xenograft, Translational Research Biomarker

Category(s): Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools