Search Results - glioblastoma

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M4N and Temozolomide Combination Therapy for Glioblastoma multiforme (GBM)

Unmet NeedGlioblastoma multiforme (GBM) is the most common malignant primary brain tumor in adults and remains one of the most aggressive types of malignancies. The mainstay of GBM treatment is surgery, radiation and adjuvant chemotherapy using temozolomide (TMZ). While treatment options have incrementally improved, survival rates remains dismal. Only...

Published: 5/9/2024 | Inventor(s): Ru Chih Huang, Jong ho Chun, Yu-Ling Lin, Yu-Chuan Liang, Kuang-Wen Liao, Tiffany Jackson, David Mold, Chien-Hsien Lai

Keywords(s): Agonists/Promoters, Brain Cancer, Cancers, Chemotherapy/Immunotherapy, Combination, Disease Indication, Glioblastoma, Glioma, Non-novel, Off-the-shelf, Predicted Novelty, Small Molecules, Therapeutic Matter, Therapeutic Substance, Therapeutics, Therapy Type

Category(s): Technology Classifications > Therapeutic Modalities > Small Molecules, Clinical and Disease Specializations > Oncology > Brain Cancer

NKCC1-pcDNA3-GFP

Invention novelty: This tangible material is a plasmid vector expressing a NKCC1-EGFP fusion protein. Value Proposition: NKCC1 (Na+-K+-Cl- cotransporter 1) regulates cell volume and accumulation of intracellular Cl- and has been shown to promote invasiveness of brain tumor cells by modulating cell adhesion and cell migration. This vector is a tool that...

Published: 5/9/2024 | Inventor(s): Tomas Garzon-Muvdi, Colette Aprhys, Alfredo Quinones-Hinojosa

Keywords(s): Basic Research Biomarker, Brain Cancer, Cancers, Cell Signaling, Cloning Reagents, Discovery/Research Tools, Disease Indication, Glioblastoma, Glioma, Molecular Switches/Receptors, Plasmid, Recombinant Proteins, Research Reagent

Category(s): Technology Classifications > Research Tools > Proteins, Ligands & Receptors, Technology Classifications > Research Tools > Vectors & Plasmids, Technology Classifications > Research Tools, Clinical and Disease Specializations > Oncology > Brain Cancer