Search Results - clinical+and+disease+specializations+%3e+cardiovascular+%3e+heart+failure

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Compositions and Methods for Treating Diseases and Conditions Associated with Activation of the NLRP3 Inflammasome

Unmet NeedAutoinflammatory responses, your body’s innate defense mechanism against infections and stressors, can become overactive and cause chronic inflammation in various tissues and organs. Inflammatory diseases affect more than 200 million people worldwide and include pulmonary hypertension, scleroderma, rheumatoid arthritis, pulmonary fibrosis,...

Published: 3/14/2025 | Inventor(s): Roger Johns

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Regeneration of cardiac muscle for the treatment of heart failure

Value Proposition:This technology provides a therapeutic approach for the regrowth of permanently damaged heart muscle.This could improve health outcomes for patients with severe heart failure.Technology DescriptionResearchers at Johns Hopkins have discovered that the manipulation of circadian genes can induce the proliferation and regeneration of cardiomyocytes...

Published: 3/14/2025 | Inventor(s): Emmanouil Tampakakis

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Category(s): Clinical and Disease Specializations > Cardiovascular, Clinical and Disease Specializations > Cardiovascular > Heart Failure, Technology Classifications > Therapeutic Modalities, Technology Classifications > Therapeutic Modalities > Targets

A Multi-modal Deep Learning Method for Ventricular Arrhythmia Risk Stratification

Unmet NeedHypertrophic cardiomyopathy (HCM) is a rare genetic condition (prevalence in adults: 0.2-0.5%) that causes pathologic enlargement of the left ventricle (1). While many HCM patients live normal lives, some are at risk for severe cardiac complications, including sudden cardiac death due to ventricular arrhythmia (VA). VA risk is currently evaluated...

Published: 3/14/2025 | Inventor(s): Natalia Trayanova, Minglang Yin, Changxin Lai

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Predictors of QTVI, A Marker of Sudden Cardiac Death: Sleep Heart Health Study

Unmet NeedSudden cardiac death is the leading cause of mortality in patients with chronic heart failure. However, there isn’t a standard method of assessing risk for SCDs, which is necessary for early prevention (e.g. through the implantation of a cardioverter defibrillator). Technology OverviewThe QT Variability index, measured through an electrocardiogram,...

Published: 3/14/2025 | Inventor(s): Naresh Punjabi, Raghav Ramachandran, Hannah Cowley

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Category(s): Clinical and Disease Specializations > Cardiovascular > Heart Failure, Technology Classifications > Diagnostics > Companion Diagnostics