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Self-Assembling Antiviral Prodrugs for Long-Acting Treatment of Chronic HIV Infections

Unmet Need / Invention Novelty: The need for long-acting HIV drugs arises from challenges such as pill burden, side effects, and stigma, which contribute to inconsistent use and reduced effectiveness. A long-acting antiretroviral formulation could enhance treatment adherence, reduce disease transmission, and better support populations facing barriers...

Published: 3/14/2025 | Inventor(s): Honggang Cui, Charles Flexner, Maya Monroe, Han Wang

Keywords(s):

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Infectious Diseases, Technology Classifications > Therapeutic Modalities, Technology Classifications > Therapeutic Modalities > Peptides, Clinical and Disease Specializations > Infectious Diseases > HIV, Clinical and Disease Specializations > Infectious Diseases > HIV/AIDS, Clinical and Disease Specializations > Infectious Diseases > Hepatitis B Virus, Clinical and Disease Specializations > Infectious Diseases > Viral Infections

Quantitative method to identify the source of hepatitis B surface antigen

Unmet Need / Invention Novelty: Loss of hepatitis B surface antigen (HBsAg) is defined as a functional cure for chronic hepatitis B virus infection, but it is clinically challenged by the derivation of HBsAg from two sources that must be uniquely targeted: covalently closed circular DNA (cccDNA) and integrated HBV DNA (iDNA). Currently, no rapid method...

Published: 3/14/2025 | Inventor(s): Ashwin Balagopal, Chloe Thio, Tanner Grudda, Hyon Hwang

Keywords(s):

Category(s): Clinical and Disease Specializations > Infectious Diseases > Hepatitis B Virus, Technology Classifications > Diagnostics > Prognostic Biomarkers