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Acetylated Polyamines as Biomarkers of HIV-1 Associated Neurocognitive Disorders (HAND)

Acetylated Polyamines as Biomarkers of HIV-1 Associated Neurocognitive Disorders (HAND) Marketing Summary: Polyamines are molecules, present in all organisms, whose concentrations are regulated by the enzyme Spermine/Spermidine Acetyl transferase (SSAT). SSAT works by inactivating polyamines. Once these polyamines are inactivated they are...

Published: 3/13/2025 | Inventor(s): Kamel Khalili, Carlos Barrero, Salim Merali, Jay Rappaport, Norman Haughey, Ned Sacktor

Keywords(s): Biomarker, Clinical Diagnostics, CNS and Neurological Disorders, Cognitive Impairment, Diagnostic Biomarker, Disease Indication, HIV/AIDS, HIV-Associated Neurocognitive Disorders, In Vitro Diagnostics

Category(s): Clinical and Disease Specializations, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Diagnostics > Diagnostic Biomarkers, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Diagnostics, Clinical and Disease Specializations > Infectious Diseases, Clinical and Disease Specializations > Neurology, Clinical and Disease Specializations > Infectious Diseases > HIV/AIDS, Clinical and Disease Specializations > Neurology > Cognitive Impairment, Clinical and Disease Specializations > Neurology > HIV-Associated Neurocognitive Disorders

Machine Learning Algorithm for Delirium Prediction in the Intensive Care Unit

Unmet NeedDelirium is a potentially preventable and often reversible disorder of impaired cognition. It is common in the intensive care unit (ICU), with an overall prevalence of 32.3%. However, the prevalence is dependent on the type of patients. For example, among ventilated burn patients, the prevalence is 77%, and among mechanically ventilated patients,...

Published: 3/14/2025 | Inventor(s): Robert Stevens, Kirby Gong, Akaash Sanyal, Joanna Guo, Ryan Lu, Teya Bergamaschi, Han Kim

Keywords(s):

Category(s): Clinical and Disease Specializations > Neurology > Dementia, Clinical and Disease Specializations > Neurology > Cognitive Impairment, Clinical and Disease Specializations > Neurology, Technology Classifications > Computers, Electronics & Software > Algorithms, Technology Classifications > Computers, Electronics & Software > Artificial Intelligence, Technology Classifications > Computers, Electronics & Software > Machine Learning, Technology Classifications > Diagnostics > Prognostic Biomarkers

Smartphone-Based Head Impulse Nystagmus Test of Skew (HINTS) to Aid the Diagnosis of Patients with Vertigo and Dizziness

Unmet Need:It is estimated that 45,000-75,000 strokes are missed in emergency departments each year in the United States due to patients presenting with dizziness. Of these patients, 15,000-25,000 will have a subsequent major stroke that could’ve been prevented with earlier identification and treatment. These strokes are often missed due to the fact...

Published: 3/14/2025 | Inventor(s): David Newman-Toker, Jorge Otero-Millan, Nathan Farrell, Taylor Parker

Keywords(s): Clinical Diagnostics, Diagnostic Tool, Screening Questionnaire

Category(s): Technology Classifications > Computers, Electronics & Software > Clinical Management, Technology Classifications > Diagnostics, Clinical and Disease Specializations > Neurology > Cognitive Impairment

Glutamine Antagonists for the Treatment of Cognitive Deficits, including NeuroAIDs

Some glutamine antagonists have been shown to have anti-cancer activities in multiple preclinical and clinical studies. However the toxicity of the glutamine antagonists at doses necessary for their anticancer effects have hampered their clinical development. Herein we describe a completely novel use for the glutamine antagonists. Using a prototype...

Published: 3/13/2025 | Inventor(s): Barbara Slusher, David Volsky, Kristen Hollinger, Michael Nedelcovych, Atsushi Kamiya

Keywords(s): Antagonists/Inhibitors, CNS and Neurological Disorders, Cognitive Impairment, Disease Indication, HIV/AIDS, HIV-Associated Neurocognitive Disorders, Non-novel, Predicted Novelty, Repurposed, Small Molecules, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Infectious Diseases > HIV/AIDS, Clinical and Disease Specializations > Neurology > Cognitive Impairment, Clinical and Disease Specializations > Neurology > HIV-Associated Neurocognitive Disorders, Technology Classifications > Therapeutic Modalities > Small Molecules, Clinical and Disease Specializations > Infectious Diseases, Clinical and Disease Specializations > Neurology, Technology Classifications > Therapeutic Modalities

C11355: Therapeutic Alleviating Cognitive Impairment from Multiple Sclerosis (MS)

Novelty:This technology is a first of its kind, potential therapeutic in alleviating cognitive impairment (CI) as a result of Multiple Sclerosis (MS) and related central nervous system (CNS) autoimmune diseases.Value Proposition:CI is a debilitating outcome of many CNS disorders, including MS. Currently, the high prevalence of CI and the extremely negative...

Published: 3/13/2025 | Inventor(s): Barbara Slusher, Kristen Hollinger, Adam Kaplin

Keywords(s): Antagonists/Inhibitors, Biomarker, Clinical Diagnostics, CNS and Neurological Disorders, Cognitive Impairment, Diagnostic Biomarker, Disease Indication, In Vitro Diagnostics, Mechanism of Action Biomarker, Multiple CNS Indications, Non-novel, Predicted Novelty, Repurposed, Small Molecules, Target, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Neurology, Clinical and Disease Specializations > Neurology > Cognitive Impairment, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Diagnostics > Diagnostic Biomarkers, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Therapeutic Modalities > Small Molecules, Technology Classifications > Therapeutic Modalities > Targets, Technology Classifications > Diagnostics, Technology Classifications > Therapeutic Modalities