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Compositions and Methods for Treating Melanoma--Further Modifications

Unmet NeedTherapeutic cancer vaccines aim to activate the antitumor T cell response. These vaccines are designed to prime naïve antitumor T cells, by activating antigen presenting cells, particularly dendritic cells (DCs). DNA-based cancer vaccines are a particularly promising approach, partially due to the ease with which they can be manufactured....

Published: 6/27/2024 | Inventor(s): Richard Markham, James Gordy

Keywords(s): Biologics, Cancers, Combination, Disease Indication, Melanoma, Skin Cancer, Therapeutic Matter, Therapeutic Substance, Therapeutics, Therapy Type, Vaccine

Category(s): Clinical and Disease Specializations > Oncology > Melanoma, Clinical and Disease Specializations > Dermatology, Clinical and Disease Specializations > Oncology > Skin Cancer, Technology Classifications > Therapeutic Modalities > Immunotherapies, Technology Classifications > Therapeutic Modalities > Biologics, Technology Classifications > Therapeutic Modalities > Vaccines

Hyperspectral Imaging for Skin Cancer Detection

Invention novelty: This technology is a novel device. It can measure quantitative data, record spectral signature, and screen skin tissue for abnormalities. This hyperspectral video surveillance system can determine and assess the skin’s constitutive elements spatially and temporally, ultimately detecting abnormalities and the potential presence...

Published: 6/27/2024 | Inventor(s): Saurabh Vyas, Philippe Burlina, Amit Banerjee, Luis Garza

Keywords(s): Cancers, Clinical Diagnostics, Diagnostic Tool, Disease Indication, Measurement Tool, Skin Cancer

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Dermatology, Clinical and Disease Specializations > Oncology > Skin Cancer, Technology Classifications > Diagnostics > In Vivo Diagnostics, Technology Classifications > Diagnostics, Clinical and Disease Specializations > Oncology

JHU REF: C12704 - NOVEL STRATEGIES TO OVERCOME MELANOMA DRUG RESISTANCE

Invention novelty: Novel methods for predicting melanoma resistance to BRAF/MEK inhibitors and for treating melanoma cancer patients.Value Proposition:An estimated 76,690 new cases of invasive melanoma will be diagnosed in the US in 2013 and an estimated 9,480 people will die of melanoma in 2013. Although BRAF and MEK inhibitors have proven clinical...

Published: 6/27/2024 | Inventor(s): Dingxie Liu, Michael Xing

Keywords(s): Biomarker, Cancers, Clinical Diagnostics, Disease Indication, In Vitro Diagnostics, Melanoma, Pharmakodynamic Biomarker, Skin Cancer

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Dermatology, Clinical and Disease Specializations > Oncology > Melanoma, Clinical and Disease Specializations > Oncology > Skin Cancer, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Diagnostics, Clinical and Disease Specializations > Oncology

MART-1 Phosphopeptides Restricted by HLA-DR1 for use as Melanoma Vaccines

C10691: Novel Peptides as a Melanoma Vaccine Value Proposition: • Phosphopeptides for use as vaccines for therapy and prevention of melanoma • Phosphopeptides for robust, diverse, and long-lasting anti-tumor immunity • Specific activity against whole melanoma tumor cells in vitro • Stand alone therapy/Combination Therapy •...

Published: 6/27/2024 | Inventor(s): Donald Hunt, Florence Depontieu, Angela Zarling, Victor Engelhard, Jeffrey Shabanowitz, Jie Qian, Suzanne Topalian

Keywords(s): Biologics, Cancers, Disease Indication, Immunotherapy, Melanoma, Peptide, Single, Skin Cancer, Therapeutic Matter, Therapeutic Substance, Therapeutics, Therapy Type, Vaccine

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Dermatology, Clinical and Disease Specializations > Oncology > Melanoma, Clinical and Disease Specializations > Oncology > Skin Cancer, Technology Classifications > Therapeutic Modalities > Biologics, Technology Classifications > Therapeutic Modalities > Immunotherapies, Technology Classifications > Therapeutic Modalities > Peptides, Technology Classifications > Therapeutic Modalities > Vaccines, Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities

A p105-based NF-(kappa) B Super repressor

C04290: A p105-based NF-(kappa) B Super repressor Technical Details: Nuclear factor (NF)-kB is a family of transcription factors that regulate immune and inflammatory responses, programmed cell death (apoptosis), and developmental processes. In normal cells, NF-kB is latent, and is activated transiently by stimuli and stresses. However, under pathological...

Published: 6/27/2024 | Inventor(s): Li Lin

Keywords(s): Biologics, Cancers, Chemotherapy, Disease Indication, Nucleic Acid, Single, Skin Cancer, Therapeutic Matter, Therapeutic Substance, Therapeutics, Therapy Type

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Dermatology, Clinical and Disease Specializations > Oncology > Skin Cancer, Technology Classifications > Therapeutic Modalities > Gene Therapies, Technology Classifications > Therapeutic Modalities > Proteins, Technology Classifications > Therapeutic Modalities > Targets, Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities