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Mechanistic insights reveal drug discovery target for lithium responders and non-responders

Value PropositionNew mouse model for mood switching behavior with viability for compound screeningDemonstrated that BK channels in excitatory neurons are involved in cellular pathology of patients by affecting Ca2+ kineticsApplication to both lithium responders and non-responders Unmet NeedBipolar disorder (BPD) has a lifetime prevalence of 4-5% in...

Published: 3/14/2025 | Inventor(s): Akira Sawa, Rupali Srivastava, Koko Ishizuka

Keywords(s):

Category(s): Clinical and Disease Specializations > Psychiatry > Bipolar Disorder, Clinical and Disease Specializations > Psychiatry > Mood Disorders, Clinical and Disease Specializations > Psychiatry > Suicidal Impulses, Technology Classifications > Research Tools > Animal Models