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Mechanistic insights reveal drug discovery target for lithium responders and non-responders
Value PropositionNew mouse model for mood switching behavior with viability for compound screeningDemonstrated that BK channels in excitatory neurons are involved in cellular pathology of patients by affecting Ca2+ kineticsApplication to both lithium responders and non-responders Unmet NeedBipolar disorder (BPD) has a lifetime prevalence of 4-5% in...
Published: 3/14/2025
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Inventor(s):
Akira Sawa
,
Rupali Srivastava
,
Koko Ishizuka
Keywords(s):
Category(s):
Clinical and Disease Specializations > Psychiatry > Bipolar Disorder
,
Clinical and Disease Specializations > Psychiatry > Mood Disorders
,
Clinical and Disease Specializations > Psychiatry > Suicidal Impulses
,
Technology Classifications > Research Tools > Animal Models
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