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Design, Synthesis and Structure-activity Relationships of Pyridoquinazolinecarboxamides as RNA Polymerase I Inhibitors
This invention describes a set of novel small molecules that inhibit RNA polymerase I. RNA polymerase I (Pol I) governs the transcription of ribosomal RNAs, which are needed for building and function of the ribosomes. These ribosynthetic activities are greatly increased in cancer cells, and Pol I transcription rate is commonly deregulated in human cancers....
Published: 3/13/2025
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Inventor(s):
Marikki Laiho
,
Sara Sanders
,
Laureen Colis
,
James Barrow
,
Glen Ernst
Keywords(s):
Antagonists/Inhibitors
,
Cancers
,
Disease Indication
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Novel
,
Predicted Novelty
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Small Molecules
,
Therapeutic Matter
,
Therapeutic Substance
,
Therapeutics
Category(s):
Clinical and Disease Specializations
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Clinical and Disease Specializations > Oncology
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Technology Classifications > Therapeutic Modalities > Small Molecules
,
Technology Classifications > Therapeutic Modalities
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