Search Results - joel+credle

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Spatial Analysis of RNA Using Probe Ligation and Amplification in situ

Unmet NeedTraditional gene expression methods that use bulk RNA analysis lack the ability to resolve transcript location, and thus fail to capture the inherent cellular heterogeneity present in virtually every tissue. Abundance and localization of RNA transcripts mapped to specific regions of tissue can complement histological analysis, providing an...

Published: 3/13/2026 | Inventor(s): Harry Larman, Joel Credle

Keywords(s):

Category(s): Technology Classifications > Research Tools > Assays, Technology Classifications > Research Tools > Imaging, Technology Classifications > Research Tools > Nucleic Acids, Technology Classifications > Research Tools > Proteins, Ligands & Receptors

Ligation in situ Hybridization for highly multiplexed RNA analysis of fixed tissue specimens

Unmet Need: Formalin fixed and paraffin embedded (FFPE) tissues are the most common form of patient specimens analyzed by pathologists. This standard practice of preserving clinical samples, however, dramatically damages the RNA content of these valuable specimens. RNA molecules provide important information about which genes are being expressed in...

Published: 3/12/2026 | Inventor(s): Harry Larman, Joel Credle

Keywords(s): Discovery/Research Tools, In Vitro Research Tool

Category(s): Technology Classifications > Research Tools