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Small Molecule Inhibitors Targeting PBX1-DNA Binding to Treat Drug Resistant Cancers

Invention novelty: Panel of newly-synthesized small molecule antagonists of PBX1-DNA interaction for the treatment of different cancers and other non-neoplastic diseases. Value Proposition: Pre-B-cell leukemia homeobox-1 (PBX1) is a homeodomain transcription factor that interacts with DNA and other proteins to regulate a variety of biological processes...

Published: 3/13/2025 | Inventor(s): Tian-Li Wang, Ie-Ming Shih, Jin Jung, Mark Vaal, Alexander Stoeck

Keywords(s): Antagonists/Inhibitors, Cancers, Disease Indication, Novel, Ovarian Cancer, Predicted Novelty, Small Molecules, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities > Small Molecules, Technology Classifications > Therapeutic Modalities, Clinical and Disease Specializations > Oncology > Ovarian Cancer