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Immunotherapy delivery system to improve organ transplantation outcomes

Value PropositionNovel Therapy: Hydro(LNp), is a new therapeutic application that will improve outcomes for organ transplant recipients. Convenient Delivery: Hydro(LNp) is a two-phase delivery system that increases effectiveness in regulating transplant rejection.Broad Scope: Has the potential to adapt for applications beyond transplantation, involving...

Published: 3/14/2025 | Inventor(s): Giorgio Raimondi, Joel Schneider, Julia Patrone, Alexander Komin, Monessha Nambiar, Xiomara Calderon-Colon, Olivia Tiburzi

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Category(s): Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms

Lipid Nanoparticles as Oral Vehicles of Immunotherapy

Unmet NeedType 1 diabetes (T1D) affects 1.25 million Americans currently and by 2050, this number is expected to reach 5 million. Though a currently untreatable autoimmune disease, one of the more promising approaches has been a costimulatory blockade of malfunctioning immune cells via administration of CTLA4-Ig. However, its efficacy is impeded by...

Published: 3/14/2025 | Inventor(s): Giorgio Raimondi, Julia Patrone, Xiomara Calderon-Colon, Olivia Tiburzi

Keywords(s): Diabetes, Disease Indication, Drug Delivery Mechanism, Drug Delivery Vehicle, Immunotherapy, Metabolic Disorders, Nanoparticles, Oral Administration, Single, Therapeutic Matter, Therapeutics, Therapy Type

Category(s): Clinical and Disease Specializations > Diabetes > Type 1 Diabetes, Clinical and Disease Specializations > Diabetes, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms