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Immunotherapy delivery system to improve organ transplantation outcomes

Value PropositionNovel Therapy: Hydro(LNp), is a new therapeutic application that will improve outcomes for organ transplant recipients. Convenient Delivery: Hydro(LNp) is a two-phase delivery system that increases effectiveness in regulating transplant rejection.Broad Scope: Has the potential to adapt for applications beyond transplantation, involving...

Published: 3/14/2025 | Inventor(s): Giorgio Raimondi, Joel Schneider, Julia Patrone, Alexander Komin, Monessha Nambiar, Xiomara Calderon-Colon, Olivia Tiburzi

Keywords(s):

Category(s): Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms

Lipid Nanoparticles as Oral Vehicles of Immunotherapy

Unmet NeedType 1 diabetes (T1D) affects 1.25 million Americans currently and by 2050, this number is expected to reach 5 million. Though a currently untreatable autoimmune disease, one of the more promising approaches has been a costimulatory blockade of malfunctioning immune cells via administration of CTLA4-Ig. However, its efficacy is impeded by...

Published: 3/14/2025 | Inventor(s): Giorgio Raimondi, Julia Patrone, Xiomara Calderon-Colon, Olivia Tiburzi

Keywords(s): Diabetes, Disease Indication, Drug Delivery Mechanism, Drug Delivery Vehicle, Immunotherapy, Metabolic Disorders, Nanoparticles, Oral Administration, Single, Therapeutic Matter, Therapeutics, Therapy Type

Category(s): Clinical and Disease Specializations > Diabetes > Type 1 Diabetes, Clinical and Disease Specializations > Diabetes, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms

Cellulose-Based Hydrogels and Methods of Making Thereof

Unmet NeedHydrogels are water-insoluble polymers with the ability to swell without dissolution and to retain a large portion of solution within their structure. They have many uses, including contact lenses, wound dressings, tissue regenerative applications, orthopedic applications, drug delivery systems, sanitary napkins, cosmetic implants, and other...

Published: 3/13/2025 | Inventor(s): Julia Patrone, Morgana Trexler, Marcia Patchan, Xiomara Calderon-Colon, Jennifer Breidenich, Jeffrey Maranchi, Jennifer Elisseeff, Jenna Graham, Oliver Schein

Keywords(s): Drug Delivery Vehicle, Hydrogel, Therapeutic Matter, Therapeutics

Category(s): Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Technology Classifications > Therapeutic Modalities

Wound Healing Compositions Comprising Biocompatible Cellulose Hydrogel Membranes and Methods of Use Thereof

Unmet NeedCorneal lacerations are a common type of eye injury. These can occur in varying degrees of severity, and in many cases the wound is non-self-sealing. This type of injury requires significant intervention including sutures and, in some cases, many layers of grafts. During the course of treatment patients are required to wear bandages that can...

Published: 3/13/2025 | Inventor(s): Jennifer Elisseeff, Daniel Mulreany, Qiongyu Guo, Morgana Trexler, Jennifer Breidenich, Jeffrey Maranchi, Iossif Strehin, Jemin Chae, Oliver Schein, Russel Mccally, Jenna Graham, Julia Patrone, Marcia Patchan, Xiomara Calderon-Colon

Keywords(s): Disease Indication, Implanted Device, Implants, Therapeutic Devices, Therapeutics, Tissue Engineering/Regenerative Devices, Wound Healing

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Wound Healing, Technology Classifications > Medical Devices > Regenerative Medicine, Technology Classifications > Medical Devices > Therapeutic Devices, Technology Classifications > Therapeutic Modalities, Technology Classifications > Medical Devices

Methods to Accelerate Healing of Injured Tissues via Stem Cells in Nanofiber Patches

C12353: Stem Cell Developed Patches for Accelerated AngiogenesisNovelty: This technology describes compositions and methods of use of certain patches, with infused stem cells and/or derived growth factors, used for accelerated healing of tissue injuries.Value Proposition: Existing therapeutic angiogenesis techniques that employ individual growth factors...

Published: 3/13/2025 | Inventor(s): Xiomara Calderon-Colon, Zhiyong Xia, Chao-Wei Hwang, Peter Johnston, Virginia Bogdan

Keywords(s): Disease Indication, Implanted Device, Implants, Therapeutic Devices, Therapeutics, Tissue Engineering/Regenerative Devices, Wound Healing

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Wound Healing, Technology Classifications > Medical Devices > Therapeutic Devices, Technology Classifications > Therapeutic Modalities, Technology Classifications > Therapeutic Modalities > Stem Cells, Technology Classifications > Medical Devices