Search Results - jennifer+elisseeff

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The Role of IL17 in Age-related Immune-stromal Network Inhibiting Response to Regenerative Immunotherapy

Combination immunotherapy to enhance tissue regeneration in the elderly JHU Ref #: [C17006] Value Proposition· Regenerative medicine strategies aim to restore or replace damaged tissues and organs, with patients suffering from chronic diseases, injuries, and degenerative conditions as the end-users of regenerative medicine therapies.· Current...

Published: 1/22/2026 | Inventor(s): Jennifer Elisseeff, Jin Han, Christopher Cherry, Drew Pardoll

Keywords(s):

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Fibrosis, Clinical and Disease Specializations > Inflammation, Clinical and Disease Specializations > Traumatic Injury, Clinical and Disease Specializations > Wound Healing

Hexosamine Analogs for Regenerative Medicine and Diseases Associated with the Musculoskeletal System

Unmet Need:Osteoarthritis (OA) is the most common form of arthritis, affecting an estimated 32.5 million adults in the United States, with an increasing incidence as the population ages (see CDC) . OA is associated with considerable morbidity as a consequence of joint damage, resulting in pain, loss of joint range of motion, and disability. The disease...

Published: 1/22/2026 | Inventor(s): Kevin Yarema, Jennifer Elisseeff, Jeannine Coburn, Udayanath Aich

Keywords(s): Antagonists/Inhibitors, Arthritis, Biologics, Carbohydrates, Disease Indication, Drug Delivery Mechanism, Drug Delivery Vehicle, Joint Disorders, Novel, Osteoarthritis, Predicted Novelty, Single, Small Molecules, Targeted Therapy, Therapeutic Matter, Therapeutic Substance, Therapeutics, Therapy Type

Category(s): Clinical and Disease Specializations, Technology Classifications > Therapeutic Modalities > Small Molecules, Technology Classifications > Therapeutic Modalities > Targets, Clinical and Disease Specializations > Rheumatology, Technology Classifications > Therapeutic Modalities, Clinical and Disease Specializations > Rheumatology > Arthritis, Clinical and Disease Specializations > Rheumatology > Osteoarthritis

Cellulose-Based Hydrogels and Methods of Making Thereof

Unmet NeedHydrogels are water-insoluble polymers with the ability to swell without dissolution and to retain a large portion of solution within their structure. They have many uses, including contact lenses, wound dressings, tissue regenerative applications, orthopedic applications, drug delivery systems, sanitary napkins, cosmetic implants, and other...

Published: 1/22/2026 | Inventor(s): Julia Patrone, Morgana Trexler, Marcia Patchan, Xiomara Calderon-Colon, Jennifer Breidenich, Jeffrey Maranchi, Jennifer Elisseeff, Jenna Graham, Oliver Schein

Keywords(s): Drug Delivery Vehicle, Hydrogel, Therapeutic Matter, Therapeutics

Category(s): Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Technology Classifications > Therapeutic Modalities

Extracellular Matrix Scaffolds for Combination Immunotherapy

Unmet NeedThe critically important goal of regenerative medicine is the stimulation of in vivo wound healing and the production of functional tissue to repair or replace tissues loss to injury or disease. Extracellular matrix (ECM) materials are acellular tissue derived scaffolds commonly used in tissue regeneration following malignant or benign tumor...

Published: 1/22/2026 | Inventor(s): Jennifer Elisseeff, Matthew Wolf

Keywords(s): Cancers, Cell Therapy/Immunotherapy, Combination, Disease Indication, Implanted Device, Implants, Therapeutic Devices, Therapeutic Matter, Therapeutics, Therapy Type, Tissue Engineering/Regenerative Devices

Category(s): Clinical and Disease Specializations > Immuno-Oncology, Technology Classifications > Therapeutic Modalities > Immunotherapies, Technology Classifications > Medical Devices > Regenerative Medicine

Wound Healing Compositions Comprising Biocompatible Cellulose Hydrogel Membranes and Methods of Use Thereof

Unmet NeedCorneal lacerations are a common type of eye injury. These can occur in varying degrees of severity, and in many cases the wound is non-self-sealing. This type of injury requires significant intervention including sutures and, in some cases, many layers of grafts. During the course of treatment patients are required to wear bandages that can...

Published: 1/22/2026 | Inventor(s): Jennifer Elisseeff, Daniel Mulreany, Qiongyu Guo, Morgana Trexler, Jennifer Breidenich, Jeffrey Maranchi, Iossif Strehin, Jemin Chae, Oliver Schein, Russel Mccally, Jenna Graham, Julia Patrone, Marcia Patchan, Xiomara Calderon-Colon

Keywords(s): Disease Indication, Implanted Device, Implants, Therapeutic Devices, Therapeutics, Tissue Engineering/Regenerative Devices, Wound Healing

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Wound Healing, Technology Classifications > Medical Devices > Regenerative Medicine, Technology Classifications > Medical Devices > Therapeutic Devices, Technology Classifications > Therapeutic Modalities, Technology Classifications > Medical Devices

3D-printed Bone Extracellular Matrix Scaffold

Decellularized bone particulates are mixed with polycaprolactone (PCL) or another thermoplastic material. The material, when heated above a specific temperature, becomes a viscous liquid PCL suspension with bone particulates that can be extruded from an extrusion-based three-dimensional printer. This allows for the construction of anatomically shaped,...

Published: 1/22/2026 | Inventor(s): Warren Grayson, Jennifer Elisseeff, Ben Hung, Ethan Nyberg, Tram Nguyen

Keywords(s): Disease Indication, Implants, Skeletal Disorders, Therapeutic Devices, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Musculoskeletal, Technology Classifications > Medical Devices > Therapeutic Devices, Technology Classifications > Medical Devices

Hyaluronic Acid Binding Polymer System Transforms Tissue and Biomaterial Surfaces

We introduce a transformational biomaterial approach to engineering lubrication at the tissue surface that can be applied in a single application. Articular cartilage explants were modified with a synthetic peptide-polymer system designed to non-covalently bind HA to the tissue surface and work synergistically with HA in the local fluid environment....

Published: 1/22/2026 | Inventor(s): Michael Corvelli, Anirudha Singh, Shimon Unterman, Jennifer Elisseeff

Keywords(s): Drug Delivery Vehicle, Implanted Device, Implants, Therapeutic Devices, Therapeutic Matter, Therapeutics, Tissue Engineering/Regenerative Devices

Category(s): Technology Classifications > Medical Devices > Regenerative Medicine, Technology Classifications > Medical Devices > Therapeutic Devices, Technology Classifications > Therapeutic Modalities, Technology Classifications > Medical Devices

Biological Adhesive

C10737: Biological AdhesiveValue Proposition: Johns Hopkins researchers have developed a composition comprising a biologically compatible polymer functionalized by at least two different reactive moieties to provide a biological adhesive.Technical Details: A useful biomaterial mimics a naturally occurring material, tissue, organ and the like. However,...

Published: 1/22/2026 | Inventor(s): Jennifer Elisseeff

Keywords(s): Drug Delivery Vehicle, Polymers, Therapeutic Matter, Therapeutics

Category(s): Technology Classifications > Medical Devices > Regenerative Medicine, Technology Classifications > Therapeutic Modalities > Dendrimers & Polymers, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Technology Classifications > Medical Devices, Technology Classifications > Therapeutic Modalities

Modification of a Scaffold by Hyaluronic Acid Binding Peptide for Hyaluronic Acid Retention and Tissue Engineering Applications

C10108: Method for Improved Hyaluronic Acid Retention In VivoNovelty: This technology presents a novel use of hyaluronic acid- (HA) binding peptide to aid in the retention of HA at its injection site. This technology has applications in many areas of medicine.Value Proposition: HA is an important component of the extracellular matrix and is used in...

Published: 1/22/2026 | Inventor(s): Jennifer Elisseeff, (Hyeseung) Janice Lee (Logan), Shimon Unterman

Keywords(s): Buffer/Media Solution, Culture Media, Discovery/Research Tools, Research Reagent, Translational Research Biomarker

Category(s): Technology Classifications > Research Tools > Buffers & Media Solutions, Technology Classifications > Research Tools

Chondroitin Sulfate-based Two-component Adhesive and Hydrogel

C05068: Chondroitin Sulfate-based Two-component Adhesive and Hydrogel Value Proposition: In part, the present disclosure provides for a composition comprising at least one monomelic unit of a biologically compatible polymer functionalized with an imide to provide a tissue adhesive, a hydrogel or both. In another embodiment, at least one of the monomeric...

Published: 1/22/2026 | Inventor(s): Iossif Strehin, Jennifer Elisseeff, Xiaokun Wang

Keywords(s): Disease Indication, Drug Delivery Vehicle, Hydrogel, Implanted Device, Implants, Polymers, Therapeutic Devices, Therapeutic Matter, Therapeutics, Tissue Engineering/Regenerative Devices, Wound Healing

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Wound Healing, Technology Classifications > Therapeutic Modalities > Dendrimers & Polymers, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Technology Classifications > Therapeutic Modalities, Technology Classifications > Medical Devices > Regenerative Medicine