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Hexosamine Analogs for Regenerative Medicine and Diseases Associated with the Musculoskeletal System

Unmet Need:Osteoarthritis (OA) is the most common form of arthritis, affecting an estimated 32.5 million adults in the United States, with an increasing incidence as the population ages (see CDC) . OA is associated with considerable morbidity as a consequence of joint damage, resulting in pain, loss of joint range of motion, and disability. The disease...

Published: 3/13/2025 | Inventor(s): Kevin Yarema, Jennifer Elisseeff, Jeannine Coburn, Udayanath Aich

Keywords(s): Antagonists/Inhibitors, Arthritis, Biologics, Carbohydrates, Disease Indication, Drug Delivery Mechanism, Drug Delivery Vehicle, Joint Disorders, Novel, Osteoarthritis, Predicted Novelty, Single, Small Molecules, Targeted Therapy, Therapeutic Matter, Therapeutic Substance, Therapeutics, Therapy Type

Category(s): Clinical and Disease Specializations, Technology Classifications > Therapeutic Modalities > Small Molecules, Technology Classifications > Therapeutic Modalities > Targets, Clinical and Disease Specializations > Rheumatology, Technology Classifications > Therapeutic Modalities, Clinical and Disease Specializations > Rheumatology > Arthritis, Clinical and Disease Specializations > Rheumatology > Osteoarthritis

Short Chain Fatty Acid (SCFA) - Carbohydrate Bifunctional Hybrid Molecules with Novel Anti-cancer Properties

C04704: Short Chain Fatty Acid (SCFA) - Carbohydrate Bifunctional Hybrid Molecules with Novel Anti-cancer Properties Value Proposition: Butyrate, a natural short chain fatty acid (SCFA), is well-established to have anti-cancer properties via its ability to induce cell cycle arrest and apoptosis in cancer cells. Currently, several clinical trials are...

Published: 3/13/2025 | Inventor(s): Mark Jones, Udayanath Aich, Srinivasagopalan Sampathkumar, Christopher Campbell, Kevin Yarema

Keywords(s): Biologics, Cancers, Carbohydrates, CNS and Neurological Disorders, Disease Indication, Parkinson's Disease, Single, Targeted Therapy, Therapeutic Matter, Therapeutic Substance, Therapeutics, Therapy Type

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Neurology > Parkinson's Disease, Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities > Biologics, Technology Classifications > Therapeutic Modalities > Targets, Clinical and Disease Specializations > Neurology, Technology Classifications > Therapeutic Modalities

Novel Cardiac Glycoside Analogs as Anti-Human Cytomegalovirus (HCMV) Agents

Novelty: Novel group of cardiac glycosides shown to have effective anti-HCMV properties for HCMV infection treatment. Value Proposition: HCMV infection is a serious problem in organ transplant patients and congenitally-infected babies. The currently available systemic therapies for HCMV targeting the viral DNA polymerase are associated with significant...

Published: 3/13/2025 | Inventor(s): Ravit Boger

Keywords(s): Antagonists/Inhibitors, Biologics, Carbohydrates, Cytomegalovirus, Disease Indication, Infectious Diseases, Small Molecules, Therapeutic Matter, Therapeutic Substance, Therapeutics, Viral Infections

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Infectious Diseases > Cytomegalovirus, Clinical and Disease Specializations > Infectious Diseases > Viral Infections, Technology Classifications > Therapeutic Modalities > Biologics, Clinical and Disease Specializations > Infectious Diseases, Technology Classifications > Therapeutic Modalities, Technology Classifications > Therapeutic Modalities > Small Molecules