Search Results - philip+cole

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A Selective Inhibitor of Histone Demethylase LSD1

Unmet Need: Epigenetic regulation of gene expression is one mechanism that can be dysregulated in the development of diseases such as cancer and has specifically been implicated in the the development of therapeutic resistance mechanisms in cancer and tumor metastasis. There remains a significant need for the development of novel epigenetic therapeutic...

Published: 3/13/2025 | Inventor(s): Philip Cole, Shonoi Ming, Jay Kalin, Polina Prusevich

Keywords(s): Antagonists/Inhibitors, Biomarker, Clinical Diagnostics, CNS and Neurological Disorders, Disease Indication, Epigenetic, In Vitro Diagnostics (Old), Methylation, Novel, Predicted Novelty, Small Molecules, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Neurology, Technology Classifications > Therapeutic Modalities > Small Molecules, Technology Classifications > Therapeutic Modalities

Use of Histone Acetyltransferase Inhibitors as Novel Anti-cancer Therapies

C10974: Anti-Cancer Therapeutic BiomarkerNovelty: This technology includes a novel histone acetyltransferase (HAT) inhibitor as a therapeutic and biomarker for a vast scope of cancers.Value Proposition: Acetylation and deacetylation of histone protein lysine residues are a major mechanism for cellular regulation and are implicated in a wide variety...

Published: 3/13/2025 | Inventor(s): Philip Cole, Gai Yan, Erin Bowers, Rhoda Alani

Keywords(s): Acetylation, Antagonists/Inhibitors, Biomarker, Cancers, Clinical Diagnostics, Disease Indication, Epigenetic, In Vitro Diagnostics (Old), Non-novel, Off-the-shelf, Predicted Novelty, Single, Small Molecules, Targeted Therapy, Therapeutic Matter, Therapeutic Substance, Therapeutics, Therapy Type

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities > Small Molecules, Technology Classifications > Therapeutic Modalities > Targets, Technology Classifications > Therapeutic Modalities, Technology Classifications > Diagnostics > Biomarkers