Search Results - polina+prusevich

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A Selective Inhibitor of Histone Demethylase LSD1

Unmet Need: Epigenetic regulation of gene expression is one mechanism that can be dysregulated in the development of diseases such as cancer and has specifically been implicated in the the development of therapeutic resistance mechanisms in cancer and tumor metastasis. There remains a significant need for the development of novel epigenetic therapeutic...

Published: 3/13/2025 | Inventor(s): Philip Cole, Shonoi Ming, Jay Kalin, Polina Prusevich

Keywords(s): Antagonists/Inhibitors, Biomarker, Clinical Diagnostics, CNS and Neurological Disorders, Disease Indication, Epigenetic, In Vitro Diagnostics (Old), Methylation, Novel, Predicted Novelty, Small Molecules, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Neurology, Technology Classifications > Therapeutic Modalities > Small Molecules, Technology Classifications > Therapeutic Modalities

A p105-based NF-(kappa) B Super repressor

C04290: A p105-based NF-(kappa) B Super repressor Technical Details: Nuclear factor (NF)-kB is a family of transcription factors that regulate immune and inflammatory responses, programmed cell death (apoptosis), and developmental processes. In normal cells, NF-kB is latent, and is activated transiently by stimuli and stresses. However, under pathological...

Published: 3/13/2025 | Inventor(s): Li Lin

Keywords(s): Biologics, Cancers, Chemotherapy, Disease Indication, Nucleic Acid, Single, Skin Cancer, Therapeutic Matter, Therapeutic Substance, Therapeutics, Therapy Type

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Dermatology, Clinical and Disease Specializations > Oncology > Skin Cancer, Technology Classifications > Therapeutic Modalities > Gene Therapies, Technology Classifications > Therapeutic Modalities > Proteins, Technology Classifications > Therapeutic Modalities > Targets, Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities