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OpenCRAVAT, An Open Source Collaborative Platform for the Annotation of Human Genetic Variation

Unmet NeedGene variants are complex to interpret, involving different published methods, databases, algorithms for ranking genes and different prediction tools. Decision support frameworks were created to integrate these various resources into one environment. However, current frameworks are limited by a closed proprietary architecture, limiting its...

Published: 6/28/2024 | Inventor(s): Rachel Karchin, Kymberleigh Pagel, Michael Ryan, Rick Kim, Kyle Moad

Keywords(s): Computer and Network Systems, Computer Software, Database Management Software

Category(s): Technology Classifications > Computers, Electronics & Software > Databases, Technology Classifications > Computers, Electronics & Software > Algorithms, Clinical and Disease Specializations > Genetic Diseases, Clinical and Disease Specializations > Oncology

Associating a Subject with their Time-series Data: A Distinct Method to Get Physiological Data for a Subject While Maintaining a Level of Security by Separating Them

Unmet NeedTime-series data is essential to understanding patient progress, disease course, and response to treatment. While it is currently possible to store and access time series records, many factors are removed or not recorded, resulting in confounding variables to patient data. Thus, there exists a need for methods to filter time-series data by...

Published: 6/28/2024 | Inventor(s): Raimond Winslow, Stephen Granite

Keywords(s):

Category(s): Technology Classifications > Computers, Electronics & Software > Databases, Technology Classifications > Computers, Electronics & Software > Healthcare IT, Technology Classifications > Computers, Electronics & Software > Clinical Management, Technology Classifications > Computers, Electronics & Software > Electronic Medical Records

Digital 3D Brain MRI Arterial Territories Atlas

Unmet Need: The human cerebroarterial system is composed of a complex system of arteries that supply the brain cells with oxygen and nutrition. Cerebroarterial networks are difficult to analyze due to their composition of small and large arteries, which have a complex organization of branches and cyclic connections that varies among individuals. Analyzing...

Published: 6/28/2024 | Inventor(s): Andreia Faria, Chin-Fu Liu

Keywords(s):

Category(s): Clinical and Disease Specializations > Neurology, Clinical and Disease Specializations > Neurology > Alzheimer's Disease, Clinical and Disease Specializations > Neurology > Cerebral Aneurysm, Clinical and Disease Specializations > Neurology > Stroke, Clinical and Disease Specializations > Neurology > Cerebral Ischemia, Copyright, Technology Classifications > Computers, Electronics & Software > Databases, Technology Classifications > Computers, Electronics & Software > Image Processing & Analysis, Technology Classifications > Computers, Electronics & Software > Machine Learning, Technology Classifications > Medical Devices > Imaging, Technology Classifications > Research Tools > Imaging, Technology Classifications > Computers, Electronics & Software > Artificial Intelligence

Multi-atlas Library of Brain Gray Matter Nuclei in Susceptibility MRI

Unmet NeedDespite the extensive research on the anatomy of the human brain, there still remains many anatomical features that are difficult to characterize. Additionally, anatomical brain variation amongst individuals participating in research may contribute toward ambiguity in understanding specific structures of the brain. The brain is composed of...

Published: 6/28/2024 | Inventor(s): Andreia Faria, Xu Li

Keywords(s):

Category(s): Technology Classifications > Computers, Electronics & Software > Databases, Technology Classifications > Research Tools > Imaging, Clinical and Disease Specializations > Neurology

AI Based Medical Image Generation

Unmet NeedAdvances in medical imaging has radically changed the practice of medicine in the last few decades. Recently, machine learning techniques have been shown to produce higher fidelity images in various modalities and to aid in diagnostics (Lundervold & Lundervold, 2019). Machine learning imaging research require large datasets to be trained...

Published: 6/28/2024 | Inventor(s): Yong Du, Kevin Leung, Martin Pomper, Steven Rowe, Wenyi Shao

Keywords(s):

Category(s): Technology Classifications > Computers, Electronics & Software > Artificial Intelligence, Technology Classifications > Computers, Electronics & Software > Databases, Technology Classifications > Computers, Electronics & Software > Image Processing & Analysis, Technology Classifications > Computers, Electronics & Software > Machine Learning, Technology Classifications > Medical Devices > Imaging

Application for Clinical Trial Eligibility Screening and Enrollment

Unmet needThe eligibility screening and enrollment process for clinical trial patients is extremely important for the development of drugs, biologics, medical devices, and combination therapies. Every clinical trial has unique eligibility criteria that is used to define the patient population and every potential clinical trial patient is screened to...

Published: 6/28/2024 | Inventor(s): Hamza Hasan, Matthew Gaver, James Huang, Akila Viswanathan

Keywords(s): Computer and Network Systems, Computer Software, Database Management Software, Operations Management, Operations Optimization, Research Management

Category(s): Technology Classifications > Computers, Electronics & Software > Clinical Management, Technology Classifications > Computers, Electronics & Software > Databases, Technology Classifications > Computers, Electronics & Software > Electronic Medical Records

PhysioCloud Kafka Integrations: KafkaOpenTSDB, CarescapeKafka, KafkaADT

Unmet NeedEvery day medical institutions are deluged by a veritable tsunami of patient data. Everything from treatment history, to allergies, to real-time physiological/telemetry data can be relevant to helping caregivers the information they need to make the best possible treatment decisions for their patients and organizing that data into a coherent...

Published: 6/28/2024 | Inventor(s): Raimond Winslow, Stephen Granite

Keywords(s): Computer and Network Systems, Computer Software, Database Management Software, Operations Management, Research Management

Category(s): Technology Classifications > Computers, Electronics & Software > Databases, Technology Classifications > Computers, Electronics & Software > Clinical Management, Technology Classifications > Computers, Electronics & Software > Electronic Medical Records

Online Mendelian Inheritance In Man (OMIM TM Database)

Unmet NeedToday, the genetic base for each major Mendelian disease is know and a medical professional can make a diagnosis based on the presence of a specific defective gene. In addition, a patient’s DNA can also be tested to reveal if (s)he is predisposed to a disease. Using gene therapy, medical professionals can correct a genetic defect by introducing...

Published: 6/27/2024 | Inventor(s): Victor Mckusick

Keywords(s): Computing; Calculating; Counting, Data Processing Systems or Methods, Specifically Adapted fo~, Data Processing Systems or Methods, Specifically Adapted for, Physics

Category(s): Technology Classifications > Computers, Electronics & Software > Financial Tech, Technology Classifications > Computers, Electronics & Software, Technology Classifications > Computers, Electronics & Software > Databases

ADPriboDB: A database of ADP-ribosylated proteins

Unmet NeedPharmaceutical companies are conducting clinical trials for PARP inhibitors to treat cancer patients. There is currently only one drug approved in this class, but there is a need for continued and improved knowledge of PARP substrates. Technology OverviewJHU researchers created a database that curates the last 30 years of literature on ADP-ribosylation...

Published: 6/27/2024 | Inventor(s): Anthony Leung

Keywords(s): Antagonists/Inhibitors, Cancers, Database, Discovery/Research Tools, Disease Indication, In Silico Research Tool, Small Molecules, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Technology Classifications > Computers, Electronics & Software > Databases, Technology Classifications > Research Tools, Technology Classifications > Computers, Electronics & Software, Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities > Small Molecules

Complete Computational Solution to Accelerating Spatial Searches on the Surface of the Earth, Sky or any Sphere

Unmet NeedModern information technologies have made big data available in a variety of sciences, i.e. extremely large data sets that may be analyzed only computationally to reveal patterns, trends, and associations. There are a number of approaches to compile these data sets, but in all current approaches there are challenges in how to make sense of...

Published: 6/27/2024 | Inventor(s): Laszlo Dobos, Gyorgy Fekete, Sandor Szalay, Tamas Budavari

Keywords(s): Computing; Calculating; Counting, Electrical Digital Data Processing, Image Data Processing or Generation, Physics, Three Dimensional Modeling

Category(s): Technology Classifications > Computers, Electronics & Software > Algorithms, Technology Classifications > Computers, Electronics & Software > Databases, Technology Classifications > Computers, Electronics & Software

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