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Novel inhibitors of protein kinase signaling that are neuroprotective and have potential applicability for the treatment of glaucoma, optic nerve disease, and other forms of neurodegeneration - #2

Glaucoma is a major cause of visual loss and blindness in elderly Americans and throughout the world. One approach to treatment of glaucoma, and other optic nerve diseases as well as other neurodegenerations, is to develop neuroprotective agents that promote the survival of neurons. Through a high content screen of libraries of small molecule compounds,...

Published: 6/27/2024 | Inventor(s): Laszlo Hackler, Dana Ferraris, Cynthia Berlinicke, James Inglese, Tomas Vojkovsky, Joseph Steiner, Barbara Slusher, Zhiyong Yang, Donald Zack

Keywords(s): Antagonists/Inhibitors, CNS and Neurological Disorders, Disease Indication, Eye Disorders, Multiple CNS Indications, Novel, Predicted Novelty, Small Molecules, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Neurology, Clinical and Disease Specializations > Ophthalmology, Technology Classifications > Therapeutic Modalities > Small Molecules, Technology Classifications > Therapeutic Modalities

Novel Inhibitors of Protein Kinase Signaling that are Neuroprotective and have Potential Applicability for the Treatment of Glaucoma, Optic Nerve Disease, and other Forms of Neurodegeneration

Glaucoma is a major cause of visual loss and blindness in elderly Americans and throughout the world. One approach to treatment of glaucoma, and other optic nerve diseases as well as other neurodegenerations, is to develop “neuroprotective” agents that promote the survival of neurons. We have synthesized and tested a number of novel compounds, based...

Published: 6/27/2024 | Inventor(s): Tomas Vojkovsky, Cynthia Berlinicke, William Roush, Thomas Bannister, Zhiyong Yang, Donald Zack

Keywords(s): CNS and Neurological Disorders, Disease Indication, Eye Disorders, Glaucoma, Optic Nerve Diseases, Optic Neuropathy, Therapeutic Matter, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Ophthalmology > Glaucoma, Clinical and Disease Specializations > Ophthalmology > Optic Neuropathy, Technology Classifications > Therapeutic Modalities, Clinical and Disease Specializations > Ophthalmology