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Genetic Alterations Related to Anti-EGFR Therapeutic Response

Unmet Need:Colorectal cancer is the third most common cancer worldwide, with 1.2 million patients diagnosed annually. In late-stage colorectal cancer, the most commonly used targeted therapies are monoclonal antibodies, which prevent epidermal growth factor receptor (EGFR) activation. Several studies have identified alterations in KRAS and other genes...

Published: 6/27/2024 | Inventor(s): Livio Trusolino, Andrea Bertotti, Victor Velculescu, Vilmos Adleff, Eniko Papp

Keywords(s): Biomarker, Cancers, Colorectal Cancer, Disease Indication, Pharmakodynamic Biomarker, Therapeutic Matter, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Gastroenterology, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Therapeutic Modalities > Targets, Technology Classifications > Diagnostics, Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities, Clinical and Disease Specializations > Oncology > Colorectal Cancer

Prognostic Markers in Pancreatic Cancer

TITLE: GENOMIC ALTERATIONS IN THE TUMOR AND CIRCULATION OF PANCREATIC CANCER PATIENTSCASE NUMBER: C13433UNMET NEEDSeveral genetic alterations have been identified in pancreatic cancers, including those in certain tumor suppressor genes and in oncogene. Although the discoveries of these genes and their pathways have provided important insights into...

Published: 6/27/2024 | Inventor(s): Victor Velculescu, Mark Sausen, Vilmos Adleff, Jillian Phallen

Keywords(s): Biomarker, Cancers, Clinical Diagnostics, Disease Indication, In Vitro Diagnostics, Pancreatic Cancer, Prognostic Biomarker, Therapeutic Matter, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Gastroenterology, Clinical and Disease Specializations > Oncology > Pancreatic Cancer, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Diagnostics > Prognostic Biomarkers, Technology Classifications > Diagnostics > Prognostics Biomarkers, Technology Classifications > Diagnostics, Clinical and Disease Specializations > Oncology