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A Novel Method to Efficiently Synthesize a Biodegradable Dextran to Use as an Efficient Cationic Nanopolymer Carrier for siRNA Delivery

Unmet NeedIn theory, RNA interference (RNAi) can be used to decrease expression of any gene driving a disease or pathology, but has seen limited clinical usage as gene therapy due to technical issues, i.e., small interfering RNA (siRNA) cannot enter cells efficiently due to their weight and charge. As such, a carrier molecule is needed to bring siRNA...

Published: 6/27/2024 | Inventor(s): Zaver Bhujwalla, Zhihang Chen

Keywords(s): Biologics, Cancers, Disease Indication, Drug Delivery Vehicle, Nucleic Acid, Polymers, Therapeutic Matter, Therapeutic Method, Therapeutic Substance, Therapeutics

Category(s): Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Technology Classifications > Therapeutic Modalities > Dendrimers & Polymers, Technology Classifications > Research Tools > Nucleic Acids

PSMA-based Theranostic Imaging of Metastatic Cancer

C11482: PSMA-based Theranostic Imaging of Metastatic CancerNovelty: This invention is a pharmaceutical composition and method for the effective imaging, targeting, and treatment of metastatic tumor cells.Value Proposition: In the United States, prostate cancer (PCa) is the second leading cause of cancer-related death among men. There is a compelling...

Published: 6/27/2024 | Inventor(s): Zhihang Chen, Cong Li, Sridhar Nimmagadda, Zaver Bhujwalla, Sangeeta Ray, Marie-France Penet, Martin Pomper

Keywords(s): Cancers, Disease Indication, Drug Delivery Vehicle, Imaging Agent, Imaging and Sensing Systems, In Vivo Medical Imaging, Nanoparticles, Prostate Cancer, Therapeutic Matter, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Men's Health, Clinical and Disease Specializations > Oncology > Prostate Cancer, Technology Classifications > Medical Devices > Imaging, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Technology Classifications > Medical Devices, Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities