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Genetic Alterations in Medulloblastomas - MLL Genes as Targets for Diagnosis and Therapeutics

Medulloblastoma (MB) is the most common malignant brain tumor of children. To identify the genetic alterations in this tumor type, we searched for copy number alterations using high density microarrays and sequenced all known protein-coding genes and miRNA genes using Sanger sequencing. We found that, on average, each tumor had 11 gene alterations,...

Published: 5/9/2024 | Inventor(s): Xiaosong Zhang, Hai Yan, Gregory Riggins, Victor Velculescu, Kenneth Kinzler, Darell Bigner, Nickolas Papadopoulos, Donald Parsons, Sian Jones, Rebecca Leary, Meng Li, Bert Vogelstein

Keywords(s): Biomarker, Brain Cancer, Cancers, Clinical Diagnostics, Diagnostic Biomarker, Disease Indication, In Vitro Diagnostics, Medulloblastoma, Therapeutic Matter, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Neurology, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Diagnostics > Diagnostic Biomarkers, Technology Classifications > Therapeutic Modalities > Targets, Technology Classifications > Diagnostics, Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities, Clinical and Disease Specializations > Oncology > Brain Cancer, Clinical and Disease Specializations > Oncology > Medulloblastoma

Long Noncoding RNAs as Therapeutic and Diagnostic Markers for Childhood Cancer Medulloblastoma

Unmet NeedMedulloblastoma (MB) is the most common pediatric brain tumor and requires aggressive therapy in high-risk cases. MB is frequently resistant to treatment and is associated with high morbidity and mortality in affected individuals. There are four distinct molecular subgroups of MB (WNT, SHH, Group 3, and Group 4), which are characterized by...

Published: 5/9/2024 | Inventor(s): Ranjan Perera, Keisuke Katsushima

Keywords(s): Biomarker, Cancers, Clinical Diagnostics, CNS and Neurological Disorders, Disease Indication, In Vitro Diagnostics (Old), Novel, Predicted Novelty, Target, Therapeutic Matter, Therapeutics

Category(s): Clinical and Disease Specializations > Oncology > Medulloblastoma, Clinical and Disease Specializations > Rare Diseases, Technology Classifications > Diagnostics > Diagnostic Biomarkers, Technology Classifications > Therapeutic Modalities > Targets

Using human neural stem cells to model brain tumors

ABSTRACTJHU researchers developed a new method to generate genetically accurate models of rare tumors, and a companion computational methodology to find therapeutic interventions that target them. They validated their human neural stem cell model of MYC-driven Group 3 medulloblastoma and showed that CDK4/6 inhibitors are active against this subgroup....

Published: 5/9/2024 | Inventor(s): Eric Raabe, Allison Hanaford, Charles Eberhart, Ulf Kahlert, Jarek Maciaczyk, Guido Nikkhah

Keywords(s): Brain Cancer, Cancers, Cell Model, Discovery/Research Tools, Disease Indication, In Vitro Research Tool, Medulloblastoma, Stem Cells

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Neurology, Clinical and Disease Specializations > Oncology > Brain Cancer, Clinical and Disease Specializations > Oncology > Medulloblastoma, Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools > Stem Cells, Clinical and Disease Specializations > Oncology, Technology Classifications > Research Tools