Search Results - acute+myeloid+leukemia

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Aldehyde Dehydrogenase Activity Distinguishes Leukemia Stem Cells from Normal Hematopoietic Stem Cells in Acute Myeloid Leukemia

Using the methods of the present invention, intermediate (int) levels of aldehyde dehydrogenase (ALDH) activity reliably distinguished leukemic CD34+CD38? cells capable of engrafting immunodeficient mice, from residual normal hematopoietic stem cells that exhibited relatively higher ALDH activity. Minimal residual disease (MRD) detected during complete...

Published: 6/27/2024 | Inventor(s): Richard Jones, Jonathan Gerber

Keywords(s): Acute Myeloid Leukemia, Biomarker, Cancers, Clinical Diagnostics, Disease Indication, Hematologic Malignancies, In Vitro Diagnostics, Leukemia, Mechanism-of-action Biomarker

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Hematology, Clinical and Disease Specializations > Oncology > Acute Myeloid Leukemia, Clinical and Disease Specializations > Oncology > Hematologic Malignancies, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Diagnostics, Clinical and Disease Specializations > Oncology

FLT3/ITD Mouse Model for Acute Myeloid Leukemia (AML)

Unmet Need: Constitutive activation of FMS-like tyrosine kinase 3 (FLT3) by internal tandem duplication (ITD) mutations is one of the most common molecular alterations known in acute myeloid leukemia (AML). To investigate the role FLT3/ITD mutations play in the development of leukemia, we generated a FLT3/ITD knock-in mouse model by inserting an ITD...

Published: 6/27/2024 | Inventor(s): Donald Small

Keywords(s): Acute Myeloid Leukemia, Blood Cancer, Cancers, Discovery/Research Tools, Disease Indication, Hematologic Malignancies, In Vivo Research Tool, Knock In Mouse Model, Mouse Model

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Hematology, Clinical and Disease Specializations > Oncology > Acute Myeloid Leukemia, Clinical and Disease Specializations > Oncology > Hematologic Malignancies, Technology Classifications > Research Tools > Animal Models, Clinical and Disease Specializations > Oncology, Technology Classifications > Research Tools