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Aldehyde Dehydrogenase Activity Distinguishes Leukemia Stem Cells from Normal Hematopoietic Stem Cells in Acute Myeloid Leukemia

Using the methods of the present invention, intermediate (int) levels of aldehyde dehydrogenase (ALDH) activity reliably distinguished leukemic CD34+CD38? cells capable of engrafting immunodeficient mice, from residual normal hematopoietic stem cells that exhibited relatively higher ALDH activity. Minimal residual disease (MRD) detected during complete...

Published: 6/27/2024 | Inventor(s): Richard Jones, Jonathan Gerber

Keywords(s): Acute Myeloid Leukemia, Biomarker, Cancers, Clinical Diagnostics, Disease Indication, Hematologic Malignancies, In Vitro Diagnostics, Leukemia, Mechanism-of-action Biomarker

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Hematology, Clinical and Disease Specializations > Oncology > Acute Myeloid Leukemia, Clinical and Disease Specializations > Oncology > Hematologic Malignancies, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Diagnostics, Clinical and Disease Specializations > Oncology