Search Results - anthony+leung

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Enzymatic labeling of poly(ADP-ribose) polymer and ADP-ribosylated proteins

Unmet NeedDysregulation of ADP-ribosylation, the process of adding ADP-ribose groups onto proteins, has been implicated in the pathogenesis of cancer, viral infection, and neurodegeneration. To date, three drugs that inhibit polyADP-ribose polymerases (PARP) have been approved by the FDA to treat ovarian and other cancers. Though a promising new therapeutic...

Published: 6/27/2024 | Inventor(s): Anthony Leung, Yoshinari Ando, Robert McPherson, Elad Elkayam, Mohsen Badiee

Keywords(s): Basic Research Biomarker, Discovery/Research Tools, Labels/Markers, Research Reagent

Category(s): Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Research Tools, Technology Classifications > Diagnostics

ADPriboDB: A database of ADP-ribosylated proteins

Unmet NeedPharmaceutical companies are conducting clinical trials for PARP inhibitors to treat cancer patients. There is currently only one drug approved in this class, but there is a need for continued and improved knowledge of PARP substrates. Technology OverviewJHU researchers created a database that curates the last 30 years of literature on ADP-ribosylation...

Published: 6/27/2024 | Inventor(s): Anthony Leung

Keywords(s): Antagonists/Inhibitors, Cancers, Database, Discovery/Research Tools, Disease Indication, In Silico Research Tool, Small Molecules, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Technology Classifications > Computers, Electronics & Software > Databases, Technology Classifications > Research Tools, Technology Classifications > Computers, Electronics & Software, Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities > Small Molecules