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Overview: These knock-out mice are deficient of endogenous Factor VIII making them useful for hemophilia A studies. The mice are available via The Jackson Laboratory Strain: 004424; B6;129S4-F8tm1Kaz/JTechnical DetailsMice that are homozygous for the targeted, X chromosome-linked mutant allele are viable and fertile. Homozygous females and carrier males...

Published: 3/13/2025 | Inventor(s): Haig Kazazian, John Gearhart, Ann Lawler, Lilia Bi

Keywords(s): Basic Research Biomarker, Discovery/Research Tools, Disease Indication, Genetic Disorders, Hemophilia, In Vivo Research Tool, Knock Out Mouse Model, Mouse Model

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Genetic Diseases > Hemophilia, Clinical and Disease Specializations > Hematology, Clinical and Disease Specializations > Rare Diseases, Technology Classifications > Research Tools > Animal Models, Clinical and Disease Specializations > Genetic Diseases, Technology Classifications > Research Tools

Hemophilia A inbred mouse

C11950: Novel Inbred Mouse Model of Hemophilia ANovelty: This invention is a transgenic inbred mouse model of Hemophilia A.Value Proposition: Currently available natural canine models of Hemophilia A are ineffective in designing gene therapy for the disease. There is a need for a mouse model to study the Factor VIII gene (Factor VIII deficiency causes...

Published: 3/13/2025 | Inventor(s): Haig Kazazian

Keywords(s): Basic Research Biomarker, Discovery/Research Tools, Disease Indication, Genetic Disorders, Hemophilia, In Vivo Research Tool, Knock Out Mouse Model, Mouse Model