Search Results - clinical+and+disease+specializations+%3e+oncology+%3e+glioblastoma

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Dendrimer-delivered alpha-particle radiotherapy for treatment of glioblastoma and possibly of other cancers in the brain

#C17436Inventor(s): Stavroula Sofou (primary), Kannan Rangaramanujam, Rajiv NairUnmet NeedGlioblastoma accounts for 49.1 percent of all primary malignant brain tumors. Although current standard of care, which includes surgery, followed by radiotherapy, and chemotherapy, may prolong survival, the five-year survival rate for glioblastoma patients is only...

Published: 9/27/2024 | Inventor(s): Stavroula Sofou, Kannan Rangaramanujam, Rajiv Nair

Keywords(s):

Category(s): Clinical and Disease Specializations > Oncology > Glioblastoma, Clinical and Disease Specializations > Oncology, Clinical and Disease Specializations > Immuno-Oncology, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms

Neutrophil Suppression as Preconditioning to Increase Efficacies and Safety of Oncolytic Bacterial Therapies

Unmet NeedHypoxia is a prominent feature of solid tumors and can function as fertile environment for oncolytic anaerobic bacteria such as Clostridium novyi-NT (C. novyi-NT) where it can induce tumor destruction in mice and patients. However, two major obstacles have limited its use, namely the host inflammatory response and the incomplete clearance...

Published: 9/27/2024 | Inventor(s): Renyuan Bai, Verena Staedtke

Keywords(s):

Category(s): Clinical and Disease Specializations > Oncology, Clinical and Disease Specializations > Oncology > Glioblastoma, Clinical and Disease Specializations > Immuno-Oncology, Technology Classifications > Therapeutic Modalities > Targets

Targeted Liposomes Encapsulating miR-603 Complexes

Unmet Need: Glioblastoma (GBM) is the most common malignant brain tumor in adults, affecting 17K patients in the US annually. GBM stem cells underlie GBM recurrence, leading to treatment resistance and poor patient outcomes. Standard treatments remove the primary tumor cells but leave space for GBM stem cells to cause tumorigenesis. There is a need...

Published: 9/27/2024 | Inventor(s): Efrosini Kokkoli, Clark Chen, Zachary Schneiderman

Keywords(s):

Category(s): Clinical and Disease Specializations > Neurology, Clinical and Disease Specializations > Oncology > Glioblastoma, Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities