Search Results - clinical+and+disease+specializations+%3e+ophthalmology+%3e+dry+age-related+macular+degeneration

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Dual-Target Vascular Endothelial Growth Factor (VEGF) Therapy for Treating Ocular Neovascularization

Value Proposition· Comprehensive Targeting: Engineered antagonist proteins combine elements of both VEGF receptor (VEGFR)-1 and VEGFR-2 to target all human VEGF ligands and sequester 2 ligand homodimers simultaneously.· Superior Inhibition: Comprehensive ligand blockade inhibits neovascularization more effectively than existing VEGF-A only...

Published: 4/24/2026 | Inventor(s): Jamie Spangler, Raquel Formica, Peter Campochiaro, Paul Sargunas

Keywords(s):

An ex vivo Model for Rapid Evaluation of Choroidal Mast Cell Degranulation

Unmet NeedAlmost 11 million people in the United States have symptoms of age-related macular degeneration (AMD). AMD is a multifactorial disease distinguished by progressive degeneration in the macular region of the eye, resulting in irreversible central vision loss among the elderly population. Current evidence suggests that inflammation plays a vital...

Published: 4/24/2026 | Inventor(s): Gerard Lutty, Shuntaro Ogura

Keywords(s): Discovery/Research Tools, Disease Indication, Eye Disorders, In Vitro Research Tool, In Vivo Research Tool, Macular Degeneration, Rat Model, Target-based Screening Tool

Category(s): Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools > Assays, Clinical and Disease Specializations > Ophthalmology > Macular Degeneration, Clinical and Disease Specializations > Ophthalmology > Dry Age-Related Macular Degeneration