🔍
Search Results - epilepsy
4
Results
Sort By:
Published Date
Updated Date
Title
ID
Descending
Ascending
Rufinamide derivatives as novel drugs against
epilepsy
syndromes caused by aberrant sodium channel behavior
Unmet NeedLennox-Gastaut Syndrome (LGS) is rare and severe form of childhood-onset
epilepsy
associated with various types of seizures and cognitive dysfunction that persist into adulthood; yet, to date, LGS management is challenged by the lack of reliable diagnostic tests and potentially grave side-effects of available therapeutics. Rufinamide is a...
Published: 3/13/2025
|
Inventor(s):
Frank Bosmans
,
Dimpy Kalia
Keywords(s):
Antagonists/Inhibitors
,
CNS and Neurological Disorders
,
Disease Indication
,
Epilepsy
,
Genetic Disorders
,
Novel
,
Predicted Novelty
,
Small Molecules
,
Therapeutic Matter
,
Therapeutic Substance
,
Therapeutics
Category(s):
Clinical and Disease Specializations
,
Technology Classifications > Therapeutic Modalities > Small Molecules
,
Clinical and Disease Specializations > Neurology
,
Technology Classifications > Therapeutic Modalities
,
Clinical and Disease Specializations > Neurology >
Epilepsy
,
Clinical and Disease Specializations > Rare Diseases
Method for Treating Refractory Seizures Using a Novel Therapeutic Approach
Technology OverviewThe invention provides novel pharmaceutical interventions that convert phenobarbital (PB)-resistant seizures into phenobarbital responsive seizures in neonates. We have shown that unlike in adult brains, expression of a transport protein in the neonatal brain is much lower and undergoes further down-regulation following an ischemic...
Published: 3/13/2025
|
Inventor(s):
Shilpa Kadam
Keywords(s):
Agonists/Promoters
,
CNS and Neurological Disorders
,
Disease Indication
,
Epilepsy
,
Novel
,
Predicted Novelty
,
Small Molecules
,
Therapeutic Matter
,
Therapeutic Substance
,
Therapeutics
Category(s):
Clinical and Disease Specializations
,
Clinical and Disease Specializations > Neurology >
Epilepsy
,
Technology Classifications > Therapeutic Modalities > Small Molecules
,
Clinical and Disease Specializations > Neurology
,
Technology Classifications > Therapeutic Modalities
Novel Triazole Compounds to Treat Nav1.6-related Brain Disorders
Unmet NeedAbnormal behavior of sodium (Nav) channels is linked to a variety of
epilepsy
syndromes, movement disorders, and neuropathic pain. While researchers continue to elucidate the roles of different Nav channel isoforms within a variety of neurological disorders, current therapeutics influence numerous Nav channel isoforms, resulting in off-target...
Published: 3/13/2025
|
Inventor(s):
Frank Bosmans
,
Dimpy Kalia
Keywords(s):
Antagonists/Inhibitors
,
CNS and Neurological Disorders
,
Disease Indication
,
Epilepsy
,
Neuropathy
,
Non-novel
,
Novel
,
Off-the-shelf
,
Predicted Novelty
,
Small Molecules
,
Therapeutic Matter
,
Therapeutic Substance
,
Therapeutics
Category(s):
Clinical and Disease Specializations
,
Clinical and Disease Specializations > Neurology
,
Technology Classifications > Therapeutic Modalities > Small Molecules
,
Technology Classifications > Therapeutic Modalities
,
Clinical and Disease Specializations > Neurology > Neuropathy
,
Clinical and Disease Specializations > Neurology >
Epilepsy
Novel Triazole Compounds to Treat Brain Disorders
Unmet NeedAbnormal behavior of sodium (Nav) channels is linked to a variety of
epilepsy
syndromes, movement disorders, and neuropathic pain. While researchers continue to elucidate the roles of different Nav channel isoforms within a variety of neurological disorders, current therapeutics influence numerous Nav channel isoforms, resulting in off-target...
Published: 3/13/2025
|
Inventor(s):
Frank Bosmans
,
Jeet Kalia
Keywords(s):
Antagonists/Inhibitors
,
Assay
,
Clinical Diagnostics
,
CNS and Neurological Disorders
,
Disease Indication
,
Epilepsy
,
In Vitro Diagnostics
,
Novel
,
Predicted Novelty
,
Small Molecules
,
Therapeutic Matter
,
Therapeutic Substance
,
Therapeutics
Category(s):
Clinical and Disease Specializations
,
Clinical and Disease Specializations > Neurology
,
Technology Classifications > Therapeutic Modalities > Small Molecules
,
Technology Classifications > Therapeutic Modalities
,
Clinical and Disease Specializations > Neurology >
Epilepsy
,
Technology Classifications > Research Tools > Assays
JHTV Home
|
Search
|
Login/Subscribe
2017 - 2022 © Johns Hopkins Technology Ventures. All Rights Reserved. Powered by
Inteum