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Using human neural stem cells to model brain tumors

ABSTRACTJHU researchers developed a new method to generate genetically accurate models of rare tumors, and a companion computational methodology to find therapeutic interventions that target them. They validated their human neural stem cell model of MYC-driven Group 3 medulloblastoma and showed that CDK4/6 inhibitors are active against this subgroup....

Published: 3/13/2025 | Inventor(s): Eric Raabe, Allison Hanaford, Charles Eberhart, Ulf Kahlert, Jarek Maciaczyk, Guido Nikkhah

Keywords(s): Brain Cancer, Cancers, Cell Model, Discovery/Research Tools, Disease Indication, In Vitro Research Tool, Medulloblastoma, Stem Cells

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Neurology, Clinical and Disease Specializations > Oncology > Brain Cancer, Clinical and Disease Specializations > Oncology > Medulloblastoma, Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools > Stem Cells, Clinical and Disease Specializations > Oncology, Technology Classifications > Research Tools