Search Results - fengtian+xue

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Novel eIF2α kinase target and small molecule inhibitors for modulating translation and the stress response

Unmet Need / Invention Novelty: Few kinases have been identified that phosphorylate eukaryotic initiation factor 2 alpha (eIF2α) and control translation in response to protein unfolding stress, a common cause of various neurodegenerative diseases. There is an unmet need to identify novel eIF2α kinase targets modulating translation and stress-responses...

Published: 9/12/2025 | Inventor(s): Jiou Wang, YuNing Lu, Fengtian Xue

Keywords(s):

Category(s): Technology Classifications > Therapeutic Modalities > Small Molecules

Modulation of Bio-electrical Rhythms Via a Novel Engineering Approach

Spontaneous cellular electrical rhythms govern numerous biological processes from the autonomous beating of the heart, to respiratory rhythms and insulin secretion. For instance, abnormal pacing in the heart leads to various forms of electrical disorders that necessitate conventional pharmacologic interventions and implantation of costly electronic...

Published: 9/11/2025 | Inventor(s): Hee Cheol Cho, Tian Xue, Eduardo Marban, Suk-Ying Tsang, Ronald Li

Keywords(s): Biologics, Gene Therapy, Nucleic Acid, Single, Therapeutic Matter, Therapeutic Substance, Therapeutics, Therapy Type

Category(s): Technology Classifications > Therapeutic Modalities > Biologics, Technology Classifications > Therapeutic Modalities > Gene Therapies, Technology Classifications > Therapeutic Modalities