Search Results - kalina+hristova

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A peptide that forms pores in membranes at acidic pH for the delivery of macromolecules through the plasma membrane or endosomes, or the lysis of cancer cells.

Unmet Need There are significant roadblocks to the routine delivery of macromolecules such as proteins, peptides, imaging agents, polysaccharides and more to the cytosol of mammalian cells. While most macromolecules are easily directed to existing cellular uptake mechanisms, they are often trapped in endosomal pathways leading to lysosomal degradation...

Published: 3/12/2026 | Inventor(s): Kalina Hristova, Gregory Wiedman, William Wimley, Sarah Kim

Keywords(s): Biologics, Drug Delivery Vehicle, Peptide, Peptides/Prodrugs, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Technology Classifications > Therapeutic Modalities > Peptides, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Technology Classifications > Therapeutic Modalities > Biologics, Technology Classifications > Therapeutic Modalities

Method for Reversible Blood-brain Barrier Opening Using Melittin and Melittin Variants

C15524 Marketing Summary: Method for reversible blood-brain barrier opening using melittin and melittin variants Inventors: Peter Charles Searson, Kalina Hristova, Raleigh Linville, Alexander Komin, Piotre Walczak Unmet NeedThe blood-brain barrier (BBB) is responsible for regulating the brain microenvironment by tightly controlling the entry of molecules...

Published: 3/13/2026 | Inventor(s): Peter Searson, Kalina Hristova, Raleigh Linville, Alexander Komin, Piotr Walczak

Keywords(s):

Category(s): Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms

Johns Hopkins University PROTEIN-DB2 Database System

C04853: Johns Hopkins University PROTEIN-DB2 Database SystemNovelty: The current invention is a relational database for proteomic experiments.Value Proposition: Proteomic data collection follows complex workflow, ranging from gel electrophoresis to mass spectrometry to liquid chromatography or a combination thereof. In addition, amplification of low-abundance...

Published: 3/12/2026 | Inventor(s): Raimond Winslow, Stephen Granite, Chunguang Yang, Ali Ali, Donita Robinson

Keywords(s): Computer and Network Systems, Computer Software, Computing; Calculating; Counting, Data Processing Systems or Methods, Specifically Adapted fo~, Data Processing Systems or Methods, Specifically Adapted for, Physics

Category(s): Technology Classifications > Computers, Electronics & Software > Financial Tech, Technology Classifications > Computers, Electronics & Software, Technology Classifications > Computers, Electronics & Software > Databases